goitrin/carcinogenesis

N-nitrosamides are known as direct-acting carcinogens at the site of their formation; they do not need any metabolic activation in vivo. The conditions leading to their formation in the stomach, and also their genotoxicity, have been thoroughly studied with some model compounds. Several reports link

Previous studies have shown that dietary R-goitrin is a potent inducer of hepatic glutathione S-transferase (GST) and epoxide hydrolase activities but has no effect on components of the mixed function oxidase system (ethoxycoumarin O-deethylase and cytochrome P-450). In the present work effects of

As commonly depicted, in the thione form, thionamides (including thiourea and its derivatives) bear little resemblance to thyroid hormone. However, if placed in the thiol resonance form, these molecules are noted to structurally mimic the end of the tyrosine molecule (the precursor of thyroid

Toxic components of natural foodstuffs are discussed, with special reference to lathyrogens, pressor amines, azoxyglycosides, and labile sulfur compounds. The osteolathyrogen, gamma-glutamyl-beta-aminopropionitrile, in sweet pea (Lathyrus odoratus) seeds induces skeletal deformities and aortic

In this review, some common food plants and their toxic or otherwise bioactive components and mycotoxin contaminants have been considered. Crucifers contain naturally occurring components that are goitrogenic, resulting from the combined action of allyl isothiocyanate, goitrin, and thiocyanate.