The active treatment arm will receive active grass pollen immunotherapy tablet (AIT), Grazax Oral Lyophilisate 75,000 standardised quality units tablet (SQ-T) once daily.

This arm will receive Grazax placebo once daily which contains the same composition as in the active Grazax tablet with the only difference being the exclusion of the grass pollen allergen extract.

The active treatment arm received active grass pollen immunotherapy tablet, Grazax Oral Lyophilisate 75,000 standardised quality units tablet once daily.

Grazax

This arm received Grazax placebo once daily which contains the same composition as in the active Grazax tablet with the only difference being the exclusion of the grass pollen allergen extract.

Grazax Placebo

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Region of Enrollment

Specific Immunoglobulin E (IgE)

The total nasal symptom score at one hour after grass pollen nasal allergen challenge in active versus placebo treated participants after treatment period. Score ranges from minimum 0 point to maximum of 12 points. Higher score is more severe symptoms.

Total Nasal Symptom Score After Nasal Allergen Challenge (NAC)

Mean Diameter in millimetre of EPR skin responses to intradermal grass pollen allergen injection at 12 months in active versus placebo treated participants. The larger the diameter the worst symptoms.

Early Phase Intradermal Test

Mean Diameter in millimetre of LPR skin responses to intradermal grass pollen allergen injection at 12 months in active versus placebo treated participants. The larger the diameter the worst symptoms

Late Phase Intradermal Test

Nasal patency assessed at 60 minutes after nasal allergen challenge 12 months after treatment. The lower the peak nasal inspiratory flow the blockage nasal patency is.

Change From Baseline in Delta Peak Nasal Inspiratory Flow in L/Min

Hayfever symptoms during last pollen season after start of treatment. Score on a scale ranges from minimum 0 point to maximum of 100 points. Higher score is more severe symptoms.

End of Season Global Rhinitis Symptoms

The active treatment arm received active grass pollen immunotherapy tablet (AIT), Grazax Oral Lyophilisate 75,000 standardised quality units tablet (SQ-T) once daily.
Grazax: The active treatment arm will receive active grass pollen immunotherapy tablet (AIT), Grazax Oral Lyophilisate 75,000 SQ-T once daily.

This arm received Grazax placebo once daily which contains the same composition as in the active Grazax tablet with the only difference being the exclusion of the grass pollen allergen extract.
Grazax Placebo: This arm will receive Grazax placebo once daily which contains the same composition as in the active Grazax tablet with the only difference being the exclusion of the grass pollen allergen extract.

Overall Study

Stephen R Durham

Allergic Rhinitis

The active treatment arm will receive active grass pollen immunotherapy tablet (AIT), Grazax Oral Lyophilisate 75,000 SQ-T once daily.

NHS Royal Brompton Hospital

Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study

Randomised Placebo-controlled Study of Grass Pollen Allergen Immunotherapy Tablet (AIT) for Seasonal Rhinitis: Time Course of Nasal, Cutaneous and Immunological Outcomes

Stephen Durham

Professor of Allergy and Respiratory medicine

Imperial College London

King's College London

ALK-Abelló A/S

Wellcome Trust

Patients will undergo elective bariatric surgery with ropivacaine diluted in normal saline injected along the stomach region at the end of the surgical procedure.

Patients will undergo elective bariatric surgery with only normal saline injected along the stomach region at the end of the surgical procedure.

Overweight and Obesity

Bariatric Surgery Candidate

Patient undergo elective bariatric surgery will receive 20mL of 150mg ropivacaine (0.75%) diluted in 180mL normal saline to be injected through a catheter along the greater curvature and left subdiaphragmatic region of the stomach at the end of the surgical procedure. After the surgery, the medical doctors or nurses in the ward that is not otherwise involved in this research will assess and record the pain score using visual analog scale (VAS) (0-10). The abdomen and shoulder tip pain intensity will be rated at two, four, six, eight, 24 and 48 hours postoperatively.

Ropivacaine

Patient undergo elective bariatric surgery will receive 200mL normal saline to be injected through a catheter along the greater curvature and left subdiaphragmatic region of the stomach at the end of the surgical procedure. After the surgery, the medical doctors or nurses in the ward that is not otherwise involved in this research will assess and record the pain score using visual analog scale (VAS) (0-10). The abdomen and shoulder tip pain intensity will be rated at two, four, six, eight, 24 and 48 hours postoperatively.

Normal saline

Hospital Serdang

Hospital Kuala Lumpur

Intraperitoneal Local Anesthetic in Bariatric Surgery Study (iLABS Study)

Intraperitoneal Local Anesthetic in Bariatric Surgery: A Double Blind-randomized Controlled Pilot Trial

Dr. Tikfu Gee

Senior lecturer/ consultant

The study will involve two groups with equal allocation of patients in the test group (local anaesthesia) and control group (normal saline) by randomization. All patients who agree to participate in this study will be randomized into one of the study groups.

Primary Central Nervous System Lymphoma

Methotrexate

Methylprednisolone

Temozolomide

Changhua Christian Hospital

China Medical University Hospital

National Cheng Kung University Hospital

Mackay Memorial Hospital

a Phase II Study in Primary Central Nervous System Lymphoma

High-Dose Methotrexate Plus Steroid Followed by Concurrent Whole Brain Chemoradiation With Temozolomide for Immunocompetent Patients With Primary Central Nervous System Lymphoma - a Phase II Study

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Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study

Intraperitoneal Local Anesthetic in Bariatric Surgery Study (iLABS Study)

a Phase II Study in Primary Central Nervous System Lymphoma

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