Diabetes Mellitus

Cardiovascular Diseases

Hamad Medical Coorporation

Qatar Cardiometabolic Registry

Hamad Medical Corporation

intervention 1: metoprolol Intervention 2: intravenous lipid emulsion

intervention 1: metoprolol intervention 2: Sodium chloride 0.9% solution - lipid emulsion dummy

intervention 1: Sodium chloride 0.9% solution - metoprolol dummy intervention 2: intravenous lipid emulsion

intervention 1: Sodium chloride 0.9% solution - metoprolol dummy intervention 2: Sodium chloride 0.9% solution - lipid emulsion dummy

Drug Overdose

Overdose of Beta-adrenergic Blocking Drug

Blood Pressure

One hundred and twenty ml, 0.5 mg metoprolol/ml (as metoprolol tartrate) is administered as an intravenous bolus injection followed by a continuous infusion. Infusion is halted if heart rate drops below 35 bpm or systolic blood pressure drops below 80 mm Hg, or the participant experiences subjective side effects. Infusion stops at T=30 minutes.

metoprolol

Intravenous lipid emulsion 20 % is administered as an intravenous bolus infusion (1.5 ml/kg) followed by continuous infusion (infusion rate: 0.25 ml/kg/min). Lipid emulsion infusion is stopped at T = 30 minutes.

intravenous lipid emulsion

Isotonic 0.9 % sodium chloride solution is administered as an intravenous bolus infusion (1.5 ml/kg), followed by continuous infusion (infusion rate: 0.25 ml/kg/min). Infusion is stopped at T = 30 minutes.

Sodium chloride 0.9% solution - lipid emulsion dummy

Saline solution is administered as an intravenous bolus injection followed by a continuous infusion to T=30 minutes.

Sodium chloride 0.9% solution - metoprolol dummy

Bispebjerg University Hospital Copenhagen

Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Arterial catheter connected to a pressure transducer records heart rate (beats per minute).

Blood samples drawn from an antecubital vein.

Paracetamol is used as a tool for measuring gastric emptying time.

Blood samples drawn from an antecubital vein measuring alanine aminotransferase, aspartate aminotransferase, albumin, bilirubin, alkaline phosphatase, calcium, creatine kinase, creatinine, C-reactive protein, high density lipoprotein, potassium, sodium, glucagon, lactate dehydrogenase, haptoglobin, triglycerides, and whole blood glucose levels(measured with a glucose meter).

Blood samples drawn from an antecubital vein measuring plasma metoprolol.

Stroke volume (mL) derived from arterial pulse contour analysis.

Arterial catheter connected to a pressure transducer records blood pressure in mm Hg.

Stroke volume (ml) derived from arterial pulse contour analysis.

Mikkel Bring Christensen

MD, PhD

The patients under the age of 35 followed at the consultation of rythmology for a cardiovascular assessment and already smoking the electronic cigarette and this since at least 1 month. The patient will receive a clinical examination, an electrocardiogram, a Holter-ECG and an echocardiogram before and after electronic cigarette consumption for 15 minutes.

CARDIOVASCULAR DISEASES

Assesment of patients, using electronic cigarette, presenting to the Rhythm of consultation for a cardiovascular evaluation by:
A compendium of history, a general physical examination (weight, height) and cardiovascular with measurement of oxygen saturation, an assessment of past and current smoking (with documentation of the concentration of nicotine in the electronic cigarette and the product brand used)
measurement of blood pressure
An electrocardiogram
A Holter-ECG 10 minutes
A transthoracic echocardiogram

heart arrest/nicotine

Qatar Cardiometabolic Registry

Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Study of the Immediate Cardiovascular Effects of Electronic Cigarette in Subjects With Cardiovascular Disease

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