Administration of an intravenous bolus injection of 10 mg Chlorpromazine to investigate the effect on esophageal sensitivity.

Administration of an intravenous bolus injection of saline (placebo) as the control condition of chlorpromazine in this cross-over study.

Esophageal Reflux

an intravenous bolus injection of Chlorpromazine will be administered . After an incubation period of 15 minutes esophageal sensitivity will be assessed by multimodal stimulation to evaluate the effect of dopamine antagonism on esophageal sensitivity

Chlorpromazine

The multimodal esophageal probe allows to perform 4 types of stimulations in the esophagus (thermal, mechanical, electrical and chemical stimulation). These 4 modalities will be evaluated to assess esophageal sensitivity.

Multimodal stimulation probe

an intravenous bolus injection of saline (NaCl 0.9%) will be administered . After an incubation period of 15 minutes esophageal sensitivity will be assessed by multimodal stimulation.

Placebo - Concentrate

Targid, KU Leuven

The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers.

The Effect of Chlorpromazine (Largactil®), a Dopamine Receptor Antagonist, on Esophageal Sensitivity in Healthy Volunteers: a Randomized, Double-blind, Placebo-controlled Study.

Investigation of the effect of chlorpromazine on esophageal sensitivity to multimodal stimulation in a group of healthy volunteers. This will be assessed by comparing the Temperature values (°C) of the stimulation tests between the placebo and chlorpromazine condition to see if dopamine antagonism affects sensitivity to increasing temperature.

Investigation of the effect of chlorpromazine on esophageal sensitivity to multimodal stimulation in a group of healthy volunteers. This will be assessed by comparing the balloon volumes (volume in mL) of the stimulation tests between the placebo and chlorpromazine condition to see if dopamine antagonism affects sensitivity to increasing balloon volume.

Investigation of the effect of chlorpromazine on esophageal sensitivity to multimodal stimulation in a group of healthy volunteers. This will be assessed by comparing the tolerated intensity of the electrical pulses (mA) of the stimulation tests between the placebo and chlorpromazine condition to see if dopamine antagonism affects sensitivity to increasing intensity of electrical pulses.

Investigation of the effect of chlorpromazine on esophageal sensitivity to multimodal stimulation in a group of healthy volunteers. This will be assessed by comparing the volume of infused acid (volume in mL) of the stimulation tests between the placebo and chlorpromazine condition to see if dopamine antagonism affects sensitivity to acid infusion.
Investigation of the effect of chlorpromazine on esophageal sensitivity to multimodal stimulation in a group of healthy volunteers. This will be assessed by comparing the volume of infused acid (ml) of the stimulation tests between the placebo and chlorpromazine condition to see if dopamine antagonism affects sensitivity to increasing intensity of electrical pulses.

Universitaire Ziekenhuizen Leuven

a randomized, double-blind, placebo-controlled study

Sessions will run in a double-blind randomized-controlled way. The order of placebo and chlorpromazine administration will be randomized by an online randomization tool (http://www.randomization.com/). The randomization scheme will be carried out by an experienced independent researcher or study nurse, this person will prepare and inject chlorpromazine or placebo. In this way, the investigator performing the actual study and data analysis will be blinded until termination of the study.

Self-help intervention is defined as any manual or programme to be used by individuals to assist a quit attempt not aided by counsellors or group support.They include written materials on the health effects of tobacco, audio-or video tape or computer programmes.

Telephone counseling is a way of providing individual counseling via telephone conversation or telephone hotlines. It can be proactive or reactive.

Behavioural therapy includes multiple sessions of Focus Group Discussion (FGD) and individual tobacco cessation counseling sessions. The participants in this group will be given advice to quit tobacco via multisession formal cognitive-behavioural therapy as per the Tobacco Cessation Clinic (TCC) guidelines.

Pharmacotherapy in the form of Nicotine Replacement Therapy based on individual need assessment to relieve withdrawal symptoms in tobacco users when trying to quit.

Compliance

Tobacco Use Cessation

This group will be given pictorial material and minimal written materials/ pamphlets describing health hazards of smokeless forms of tobacco and tips on tobacco cessation in general. The material will be interactively tailored to individual tobacco consumption characteristics and they will be followed up after 12 months.

Tobacco users: Self Help

This group will be given proactive as well as reactive counseling. Medical social workers will proactively call all participants regularly and offer tobacco cessation counseling. In addition, they will call those participants who have planned their quit dates. Dedicated independent mobile numbers with 12 hours help lines will be made available to the participants to maximise the level of support. It will be scheduled in response to the needs to answer any type of help pertaining to quitting tobacco.

Tobacco users:Telephonic counseling

Focus Group discussion:
This tobacco cessation intervention session will involve thirty minutes of focus group discussion with group behavioral therapy in groups of 5-10 individuals for reinforcement of tobacco use prevention and cessation advice. Group discussion is intended to improve understanding by exploring, sharing and reflecting psychosocial, familial, environmental issues which attribute to the problem.
Individual tobacco cessation counseling sessions:
Individual counseling is commonly used to help people who are trying to quit tobacco. The counseling adopting an interactive problem-solving approach will be done by trained Medical Social Workers providing face-to-face sessions for 10-15 minutes per participant.

Tobacco users:Behavioural therapy Only

Pharmaco Therapy will consist of:
Nicotine Chewing Gums:
Dose: 2 mg/4 mg, 10-15 pieces per day with maximum dose of 24 pieces/day depending on cravings Total Duration: 12 weeks Duration of treatment: Higher dose for 4-6 weeks, with weaning till 2-3 months Side effects: Bad taste, Throat irritation, burning in mouth, nausea, vomiting, hiccups, increased heart beat etc
Nicotine Transdermal patches:
Dose: 7 mg/10 mg/14 mg/21 mg -for 24-hours use. Total Duration: 12 weeks Duration of treatment: Higher strength patch for 2 weeks and depending on cravings will be gradually decreased till 4 weeks Side effects: Skin irritation, dizziness, sleep problems, increased heart beat etc

Tobacco users:Pharmacologic

Tata Memorial Hospital, Parel

Evaluation of Efficacy of Different Methods of Tobacco Cessation Interventions Among BEST Employees in Mumbai

Comparative Evaluation of Efficacy of Different Methods of Tobacco Cessation Interventions Among BEST Employees in Mumbai : A Randomized Controlled Trial

To study the Knowledge, Attitudes and Practices (KAP) regarding tobacco among BEST employees in Mumbai

randomly assign the BEST employees using tobacco to one of the four tobacco cessation interventions and study the compliance to the same.

To assesses rate of precancer among BEST employees

. To determine the rate of tobacco cessation after twelve months of follow-up.

Gauravi Ashish Mishra

Associate Professor & Physician

Tata Memorial Hospital

Gastroesophageal Reflux Disease

Gastro-oesophageal Reflux

Gastro-Esophageal Reflux

GERD

Symptoms of gastroesophageal reflux disease (GERD): Classification of adult subjects suffering from typical GERD symptoms and description of the most frequent symptom profiles and characteristics - European observational study

Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease.

Symptoms of Gastroesophageal Reflux Disease (GERD): Classification of Adult Subjects Suffering From Typical GERD Symptoms and Description of the Most Frequent Symptom Profiles and Characteristics - European Observational Study

The primary objective is to determine a classification of adult patients based on the presence or absence of 13 signs and symptoms characterizing GERD.

The association will be explored between weight related variables (e.g., BMI classes, waist circumference) and the found classification of patients.

The association will be explored between other GERD related factors (e.g., history of GERD, treatment) and the found classification of patients.

Janssen-Cilag International NV

This study will enroll the patients who were previously experienced dexamethasone-induced hiccup. Patients who experienced dexamethasone-induced hiccup during chemotherapy will enroll to study arm.
Run-in period * Dexamethasone 10mg-20mg q day iv during chemotherapy
▶ measure hiccup and nausea/vomiting severity
Treatment period * Methylprednisolone 60mg-125mg iv during chemotherapy
▶ measure hiccup and nausea/vomiting severity
Response will be evaluated by Common Terminology Criteria for Adverse Events version 4.0 (CTCAE) and NRS to hiccup at 24hrs after start methylprednisolone.
Nausea and vomiting will be assessed as CTCAE 4.0

Dexamethasone

Hiccup

Run-in period: dexamethasone 10-20mg q day iv during chemotherapy Treatment period: methylprednisolone 60-125mg iv during chemotherapy

Methylprednisolone

Gyeongsang University Hospital

Methylprednisolone Replacement for Dexamethasone-induced Hiccup

Pilot Study of Methylprednisolone Replacement for Dexamethasone-induced Hiuup Patients

measure the presence of hiccup and its severity 24 hous after chemotherapy

Prevention rate of nausea and vomiting 24 hours and 7 days after chemotherapy, respectively

Jung Hun Kang

Associate Professor

Gyeongsang National University Hospital

Electro-stimulation at an active (responsive) acupuncture site on the bottom of the foot.

Electro-stimulation at a inactive site on the bottom of the foot (a "placebo" site).

Liver Cancer

Liver Metastasis

Electro-Stimulation of Yongquan (K1) Acupoint

University of Texas MD Anderson Cancer Center Website

Fudan University Cancer Hospital

Effects of Acupoint Electro-stimulation on Preventing Nausea and Vomiting Induced by Cisplatin or Oxaliplatin

Vomiting and nausea will be classified according to the WHO criteria. The four levels of nausea are defined as: 0=no nausea, 1=slight nausea, 2=obvious nausea affecting normal life, and 3-4=continual and serious nausea. The four levels of vomiting are defined as: 0=no vomiting, 1=vomiting 1-2 times/day, 2=vomiting 2-4 times/day, and 3-4=vomiting 5 times/day.

hiccup/nausea

The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers.

Evaluation of Efficacy of Different Methods of Tobacco Cessation Interventions Among BEST Employees in Mumbai

Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease.

Methylprednisolone Replacement for Dexamethasone-induced Hiccup

Effects of Acupoint Electro-stimulation on Preventing Nausea and Vomiting Induced by Cisplatin or Oxaliplatin

A Comparison of Bupropion SR and Placebo for Smoking Cessation

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