There is provided a pharmaceutical composition for treatment or prevention of a neurodegenerative disease, comprising an RXR agonist as an active ingredient, which is a compound represented by formula (1) or (2). The pharmaceutical composition is effective in treatment or prevention of neurodegenerative diseases such as dementia, Parkinson's disease and multiple sclerosis with reducing side effects such as enlargement of the liver and elevation of blood triglyceride level. In these formulas, A represents CMe.sub.2, N-methyl, N-ethyl or N-isopropyl; X represents N, CH or C--CF.sub.3; Y and Z represent N or CH; R.sup.1 represents methyl, hydroxy, methoxy or ethoxy; R.sup.2 represents H, methyl or ethyl; B represents NR.sup.3 or CHR.sup.3; R.sup.3 represents alkyl; and R.sup.4 represents H, halogen, alkyl, alkenyl, aryl, alkynyl, alkoxy or acyl. ##STR00001##

NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

Pharmaceutical composition for treatment or prevention of neurodegenerative diseases

The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising these metabolites and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.

Podolski; Joseph S.

Wiehle; Ronald D.

Repros Therapeutics Inc.

Trans-clomiphene metabolites and uses thereof

Method of enhancing the bioavailability of a tocotrienol to a human for treating a disease or condition amenable to treatment with a tocotrienol, by administering a composition formulated for transmucosal delivery to the human. The composition contains at least one tocotrienol, and the disease or condition is selected from post-exercise muscle soreness, delayed onset muscle soreness, cardiac fibrosis, hypertension, inflammation, stroke, cancer, elevated cholesterol and/or triglycerides, baldness, hypertrophy and a condition resulting from radiation exposure.

hypertrophy/triglyceride

Pharmaceutical composition for treatment or prevention of neurodegenerative diseases

Trans-clomiphene metabolites and uses thereof

Transmucosal delivery of tocotrienol

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