imperialine/fritillaria pallidiflora

The extraction procedure and quantitative determination by HPLC-evaporative light scattering detection (ELSD) of the main bioactive components, namely, imperialine (1) and imperialine-3 beta-glucoside (2), of bulbs of Fritillaria pallidiflora Schrenk have been investigated. The most efficient method

OBJECTIVE To establish an HPLC (high performance liquid chromatography)-ELSD (evaporative light scattering detector) method for the quantification of chromophore-lacking imperialine (I) and imperialine-3 beta-D-glucoside (II) in bulbs of Fritillaria pallidiflora. METHODS By optimizing the

Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3β-d-glucoside (5), imperialine (6), imperialine β-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive

Three steroid alkaloids were isolated from the bulb of Fritillaria pallidiflora. On the basis of spectroscopic analysis and physico-chemical constants they were identified as imperialine, imperialine-beta-D-glucoside and peimissine.

Bulbus of Fritillaria pallidiflora, the dried bulb of F. pallidiflora, is widely used in Chinese folk medicine due to its powerful biological activities. The aim of this study was to investigate in vitro and in vivo antitumor activity of different fractions and isosteroidal alkaloids from bulbus of