isoboldine/litsea

Six aporphine alkaloids glaucine, boldine, norboldine, isoboldine, norcorydine and laurotetanine have been isolated from the ethanolic extract of the stems of LITSEA WIGHTIANA in which spasmolytic, hypothermic and blood pressure lowering activities have been confirmed.

Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)- N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were

A phytochemical investigation on the roots and stems of Litsea cubeba led to the isolation of seven isoquinolone alkaloids. By spectroscopic analysis and comparison of their 1H and 13C-NMR data with those in literatures, these alkaloids were identified as (+)-norboldine (1), (+)-boldine (2),