The role of platelet activating factor (PAF) and its inhibition by specific receptor antagonists was studied in hypersensitivity reactions in guinea pig lung parenchymal strips and in guinea pigs in vivo. Immunological challenge of isolated lung parenchymal strips with ovalbumin resulted in a
Leukotrienes (LT's) are produced in a number of hypersensitivity and in inflammatory conditions in the gastro-intestinal (GI) tract and may contribute to the pathogenesis of GI mucosal injury in their states. LT's do not appear to be produced by the GI mucosa in appreciable quantities under basal