Baseline and 3-6 month follow up visits will be arranged for all participants.
Visits will be conducted at baseline prior to initiation of mindfulness training and nutrition counseling, and at the 3-6 month follow up. Clinical and laboratory assessments will be obtained at each visit.

Burnout, Professional

Mindfulness training

Nutrition counseling and development of a personalized nutrition plan

Nutritional consult

Cleveland Clinic

The Impact of Combined Mindfulness-Based Interventions and Nutritional Counseling on Physician Burnout

The Impact of Combined Mindfulness-Based Interventions and Nutritional Counseling on Physician Burnout: A Clinical Trial

Measured at baseline and at 3-6 months for each participant to determine if intervention was effective. A higher score indicates improvement.

Change in diastolic and systolic blood pressure between baseline and 3-6 months after intervention

Change in resting heart rate between baseline and 3-6 months after intervention

Change in weight between baseline and 3-6 months after intervention

Change in insomnia scale between baseline and 3-6 months after intervention. Range from 0-24 with lower score being favorable outcome.

Self reported time spent (in hours) reviewing electronic health records

Change in total cholesterol post-intervention

Change in fasting plasma glucose post-intervention

Change in fasting insulin value post-intervention

Change in C-reactive protein levels post-intervention

Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) to assess presence of and extent of insulin resistance

Change in triglycerides post-intervention

Betul Hatipoglu

Staff Endocrinologist, Associate Professor of Medicine

All participants will receive mindfulness based training and nutritional consultation.

3% Diquafosol Tetrasodium Ophthalmic Solution

0.1% Sodium Hyaluronate Ophthalmic Solution

3% Diquafosol Tetrasodium Ophthalmic Solution
Diquafosol (Diquas): Diquafosol group used diquafosol 6 times a day during study period.

Diqufosol

0.1% Sodium Hyaluronate Ophthalmic Solution
Sodium Hyaluronate (Hyalein): Hyaluronate group used sodium hyaluronate 6 times a day during study period.

Hyaluronate

Total

Sex: Female, Male

Obstructive Meibomian Gland Dysfunction (MGD)

scale ranges (0-100). Higher values represent a worse outcome.

Ocular Surface Disease Index ± SD

tear Break-Up Time ± SD

Schirmer test ± SD

Instillation of fluorescein in both eyes. After 1 or 2 full blinks, the intensity of staining of both cornea was scored. According to the National Eye Institute (NEI) workshop grading system, the cornea was divided into five sections. The minimum staining score was 0 and the maximum staining score was 15 points (up to 3 points for each section).
0 : best score (no corneal damage) 15 : worst score (severe corneal damages)

Fluorescein staining score ± SD

Instillation of 1% lissamine green in both eyes. After 1 or 2 full blinks, the intensity of staining of both medial and lateral bulbar conjunctiva was cored. According to the National Eye Institute (NEI) workshop grading system, the conjunctiva was divided into six sections. The minimum staining score was 0 and the maximum staining score was 18 points (up to 3 points for each section).
0 : best score (no conjunctival damage) 18 : worst score (severe conjunctival damages)

Lissamine green staining score ± SD

Total High Order Aberration (HOA) changes ± SD

Uncorrected visual acuity (LogMAR) ± SD

Grade ranges (0-4+), Evaluate cells using slit-lamp biomicroscopy. The slit beam should be 1mm x 1mm.
Grade 0 : < 1 cell in field, Grade 0.5+ : 1-5 cells in field, Grade 1+ : 6-15 cells in field, Grade 2+ : 16-25 cells in fields Grade 3+ : 26-50 cells in field, Grade 4+ : 50+ cells in fields

Grade of anterior chamber cells

The OSDI questionnaire consists of 12 questions that evaluate subjective symptoms related to dry eye and vision The score ranges were between 0 and 100 scores and the higher scores represent a worse outcome.

an Ocular Surface Disease Index (OSDI) Questionnaire That is Related to Dry Eye Severity.

Schirmer paper strips were placed into the temporal one third of the lower conjunctival sac for 5 min and the wetness on the strips was measured.

Schirmer I Test Without Anesthesia That is Related to Dry Eye Severity.

Corneal HOAs and serial measurement of ocular total HOAs were evaluated using a KR-1W wavefront analyzer (Topcon Medical System, Inc., Tokyo, Japan). Serial measurement of total ocular HOAs was measured every second for 10 s after complete blinking in continuous measurement mode. The difference between the fifth and first HOA was used to evaluate the tear film instability.

Changes in HOAs After Blinking That is Related to Dry Eye Severity.

TBUT was assessed by instillation of a drop of 2% sterile fluorescein into the conjunctival sac and recording the interval between the last complete blink and the first appearance of a dry spot or disruption of the tear film.

Tear Break-up Time (TBUT) That is Related to Dry Eye Severity.

Ocular surface damage was assessed by the National Eye Institute (NEI) workshop grading system, and corneal fluorescein staining was evaluated. Instillation of fluorescein in both eyes. After 1 or 2 full blinks, the intensity of staining of both cornea was scored. According to the National Eye Institute (NEI) workshop grading system, the cornea was divided into five sections. The minimum staining score was 0 and the maximum staining score was 15 points (up to 3 points for each section).
0 : best score (no corneal damage) 15 : worst score (severe corneal damages)

Corneal Fluorescein Staining That is Related to Dry Eye Severity.

Ocular surface damage was assessed by the National Eye Institute (NEI) workshop grading system, and conjunctival LG staining were evaluated. Instillation of 1% lissamine green in both eyes. After 1 or 2 full blinks, the intensity of staining of both medial and lateral bulbar conjunctiva was cored. According to the National Eye Institute (NEI) workshop grading system, the conjunctiva was divided into six sections. The minimum staining score was 0 and the maximum staining score was 18 points (up to 3 points for each section).
0 : best score (no conjunctival damage) 18 : worst score (severe conjunctival damages)

Lissamine Green (LG) Conjunctival Staining That is Related to Dry Eye Severity

Anterior chamber inflammation was examined with a slit-lamp clinically, and divided into six grades using the Standardization of Uveitis Nomenclature (SUN) working group grading scheme.
grade 0 : <1 cell in field, grade 0.5 : 1-5 cells in field, grade 1 : 6-15 cells in field, grade 2 : 16-25 cells in field grade 3 : 26-50 cells in field, grade 4 : >50 cells in field Field size is a 1 mm X 1 mm slit beam

Grades of Anterior Chamber Cells.

Drug-related discomfort is defined as having started after eye drop instillation and lasting several minutes, occurring every time during instillation at any time up to 12 weeks into the follow-up period. Patients that had any adverse events or wanted to stop using the eye drops were excluded from the study, but these patients were included in the safety evaluation.

Number of Participants Who Stop Using the Eye Drops Due to Drug-related Discomfort

Overall Study

Dr. JinKwon Chung

Dry Eye Syndromes

Diquafosol group used diquafosol 6 times a day during study period.

Diquafosol (Diquas)

Hyaluronate group used sodium hyaluronate 6 times a day during study period.

lens/抗抑郁药

The Impact of Combined Mindfulness-Based Interventions and Nutritional Counseling on Physician Burnout

Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery

Light-Emitting Diode (LED) Light for Seasonal Affective Disorder (SAD) Treatment

科学支持的最完整的草药数据库