Total subjects 100 (Alcoholic liver disease:Alcoholics with no liver disease= 1:1) each will receive Gabapentin 2g/day divided in two doses for 24 weeks All patient will receive standard of care treatment

Total subjects 100 (Alcoholic liver disease: Alcoholics with no liver disease= 1:1)) each will receive Placebo 2g/day divided in two doses for 24 weeks All patient will receive standard of care treatment

Alcohol Dependence

Total subjects 100 (Alcoholic liver disease:Alcoholics with no liver disease= 1:1) each will receive Gabapentin 2000mg/day divided in two doses for 24 weeks.
All patients will receive standard of care treatment.

Gabapentin 2g/day divided in two doses for 24 weeks

Total subjects 100 (Alcoholic liver disease: Alcoholics with no liver disease= 1:1)) each will receive Placebo 2000mg/day divided in two doses for 24 weeks. All patients will receive standard of care treatment. Concurrent with study medication, study clinicians will provide participants with 20 minutes of weekly manual-guided counseling designed to increase motivation, abstinence, and medication compliance.

Placebo 2g/day divided in two doses for 24 weeks

Dyanand Medical College and Hospital

Treatment for Alcohol Dependence With Gabapentin

Treatment for Alcohol Dependence With Gabapentin: A Double Blind Placebo Controlled Randomized Clinical Trial

(Pattern of reduced drinking, described as no heavy episodic drinking. Heavy episodic drinking days are defined by the FDA - National Institute on Alcohol Abuse and Alcoholism (NIAAA) as days when the patient consumes more than four standard drinks (men) or more than three standard drinks (women). Responder analysis will be applied to the rate of Heavy Episodic Drinking.

Drinking urges were assessed by self-report using the Alcohol Craving Questionnaire-Short Form.

Mood was evaluated by self report with the Beck Depression Inventory II

Multiple components of sleep disturbance were assessed by self-report using the Pittsburgh Sleep Quality Index

Prof. Sandeep S Sidhu

Professor Department of Gastroenterology

Dayanand Medical College and Hospital

Patients with the age of 70 years or above, that have a serum sodium of below 130 mmol/L on admission. All patients will be routinely evaluated at admission with a standardized multidimensional geriatric assessment (MGA) consisting of a battery of validated assays.

Hyponatremia

The MGA contains the following tests:
Barthel Katz Index (activity of daily living, ADL)
Mini Mental State Test (MMST)
DemTec (dementia detection test)
Clock Test
Geriatric Depression Scale (GDS)
Tinetti Test
TUG (timed up-and-go Test)
Esslinger Transfer Scale (ETS)
Handgrip Test
Mini Nutritional Assessment (MNA)

Multidimensional Geriatric Assessment (MGA)

Department for Geriatric Medicine - University of Cologne

Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia.

Phenotypic Characterization of Neuropsychologic and Physical Performance in Geriatric Patients Suffering From Hyponatremia.

The impact of serum sodium concentration on geriatric assessment scores will be evaluated individually for each assessment score in a linear model, independent variables being a) increment of serum sodium [mmol/L] from the time of the first MGA at hospital admission to the time of the second MGA prior to discharge, and b) baseline serum sodium [mmol/L] at the time of the first MGA at hospital admission, the dependent variable being change of assessment score. A subgroup analysis will be done for SIADH patients.
The association between geriatric assessments and serum sodium [mmol/L] will be analysed by correlation analysis at the time of the first and second MGA.

To test for a possible influence of anaemia as a confounder, similar analyses will carried out using haemoglobin [g/dl] as the independent factor and compared to the above mentioned analyses.

Volker Burst

Out-of-hospital Cardiac Arrest

In hospital target temperature management to achieve a core body temperature of 36°C for 24 hours

Target temperature 36°C

In hospital target temperature management to achieve a core body temperature of 33°C for 24 hours

Target Temperature 33°C

Liverpool Hospital

North Shore Hospital

St George Hospital

General University Hospital

Copenhagen University Hospital, Rigshospitalet

San Martino Hospital

Santa Maria degli Angeli Hospital

Ospedale Universitario di Cattinaria

Centre Hospitalier de Luxembourg

Academisch Medisch Centrum, AMC

Onze Lieve Vrouwe Gasthuis

Rijnstate Hospital

Leeuwarden Hospital

Haukeland University Hospital

Oslo University Hospital, Rikshospitalet

Sahlgrenska University Hospital, Östra

Sahlgrenska University Hospital

Helsingborgs Hospital

Karlstad Central Hospital

Kungälv Hospital

Linköping University Hospital

Skåne University Hospital

Vrinnevi Hospital

Norra Älvsborgs Läns Sjukhus

Örebro University Hospital

University Hospital of Geneva

Kantonspital St Gallen

Royal Bournemouth Hospital

University Hospital of Wales

Guy's and St Thomas NHS Trust

St Georges' Hospital

Royal Berkshire NHS Foundation Trust

Target Temperature Management After Cardiac Arrest

Target Temperature Management 33°C Versus 36°C After Out-of-hospital Cardiac Arrest, a Randomised, Parallel Groups, Assessor Blinded Clinical Trial

Cerebral Performance Category, Modified Rankin Scale

Mini mental state exam (MMSE), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and two questions*
*Survivors with complete recovery defined by: MMSE ≥27 (or ≥19 on MMSE-Adult Lifestyle Functioning Interview by telephone interview), modified IQCODE ≤78, answer "No" to question 1a or "No" to question 1b, answer "Yes" to question 2.
1a. "In the last 2 weeks, did you require help from another person for your every day activities?" (If yes, 1b. "Is this a new situation following the heart arrest?") and 2. "Do you feel that you have made a complete mental recovery after your heart arrest?

CPC at hospital discharge and best CPC during the first 180 days after cardiac arrest

liver cirrhosis/seizures

Treatment for Alcohol Dependence With Gabapentin

Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia.

Target Temperature Management After Cardiac Arrest

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