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Blood volume and whole kidney and single nephron function were evaluated 2 and 10 days after nephrotoxic serum nephritis (NSN) induction in Wistar rats. Progressive proteinuria, hypervolemia and edema were observed in NSN rats. Sodium retention was associated with a progressive depression of single
Edema formation in nephrotic syndrome has been attributed to intravascular volume depletion resulting from leakage of plasma water into the interstitial space and activating secondary renal sodium retention. However, clinical studies indicate that edematous patients with nephrotic syndrome may have
OBJECTIVE
To report a rare presentation of the tubulointerstitial nephritis and uveitis syndrome.
METHODS
Case report. A 34-year-old woman underwent extensive clinical and laboratory evaluation of bilateral intermediate uveitis and optic nerve edema.
RESULTS
Laboratory evaluation and nephrology
BACKGROUND
TINU-Syndrome (Acute tubulointerstitial nephritis and uveitis) is a rare immune-mediated disease, primarily occurring in children and young women. Uveitis may precede, follow or occur concomitantly with nephritis. Corticosteroids are the mainstay of therapy.
METHODS
A 73-year old female