noradrenaline/fever

Noradrenaline (NA) microinjected into the rostromedial preoptic area (POA) elicits heat loss responses and opposes prostaglandin E(2)-induced fever. Here, I tested the hypothesis that local synthesis and release of nitric oxide (NO) mediates the NA-induced effects. The unilateral microinjection of

1. We have investigated the effects of endogenous monoamine depletion on the development of fever in rats. 2. Fever was produced in rats by a single intraperitoneal injection of Salmonella typhosa endotoxin or leucocyte pyrogen manufactured from ox blood. 3. Depletion of brain 5-hydroxytryptamine

We have measured the effects of ephedrine, adrenaline, noradrenaline and isoprenaline on halothane-induced contractures in muscle biopsies from patients potentially susceptible to malignant hyperthermia (MH). At concentrations of 4-24 mmol litre-1, ephedrine induced in vitro contractures in

1. Hyperthermia produced by noradrenaline (NA) was accompanied by increased metabolic rate and vasoconstriction of ear skin vessels and a fall in evaporation heat loss. 2. Prazosin (PRA), administered as a single injection, decreased of hyperthermia elicited by NA mainly of attenuation the processes

We investigated the effect of prazosin on experimental fever induced by E. coli lipopolysaccharide (LPS) and on noradrenaline hyperthermia in the rabbit. LPS and prazosin were administered iv and ivc, noradrenaline was administered only iv. Prazosin inhibited both LPS fever and noradrenaline

We performed a study of hyperthermia while injecting 0.05% of Noradrenaline following MMC for 10 minutes into the feeding artery of Walker-256 carcinosarcomas implanted 6 days earlier into the s.c. dorsum side of hindpaw of Wistar rats. The tumor growth rates on the 6th day after treatment by

Wistar rats were injected sc, with cells from Walker-256, which is resistant to hyperthermia. When hyperthermia was achieved by immersing the tumor at 44 degrees C for 60 minutes after injecting MMC (0.5 mg/kg), tumor growth was markedly suppressed in D-8 group, which formed many tumor vessels, but

Well established as supposed antidepressant drugs, desipramine (1.25-5 mg/kg), nisoxetine (0.625-2.5 mg/kg) and clomipramine (1.25-5 mg/kg) but not fluoxetine (2.5-40 mg/kg) or citalopram (2.5-40 mg/kg) dose-dependently potentiated TRH (40 mg/kg)-induced hyperthermia in mice. Alpha-adrenergic

To investigate whether life-long disturbed serotonin neurotransmission may result in adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress-induced hyperthermia were studied in serotonin transporter knockout rats. The noradrenalin transporter blocker atomoxetine was