osteophyte/hypoxia

BACKGROUND Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1 alpha by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of

We experienced a case who received a bone resection for ankylosing spinal hyperostosis through the anterior approach. He subsequently became asphyxic and suffered a cardiopulmonary arrest owing to a postoperative hematoma. His complaint before the surgery was sticking of his throat and dyspnea that

Humans with X-linked hypophosphatemia (XLH) and Hyp mice, the murine homolog of the disease, develop severe osteoarthropathy and the precise factors that contribute to this joint degeneration remain largely unknown. Fibroblast growth factor 2 (FGF2) is a key regulatory growth factor in

Degenerative hip arthritis is caused by the joint failing to bear the normal walk load, because of changes in the anatomical components and of some factors leading to static or dynamic unbalance of the joint surfaces. Degenerative arthritis usually evolves slowly, but its evolution is rapid under

In efforts to know the molecular backgrounds underlying the osteoarthritis (OA) development, examinations using the experimental mouse models confirmed that type X collagen (COL10A1) that is characteristic of chondrocyte hypertrophy and initiates endochondral ossification was strongly expressed in