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Everolimus inhibits mTOR kinase activity and its downstream targets by acting on mTORC1 and has anti-tumorigenic activity in ovarian cancer. Clinical and epidemiologic data find that obesity is associated with worse outcomes in ovarian cancer. In addition, obesity leads to hyperactivation of the
Obesity is a risk factor for several hormone-related cancers but evidence for an effect on risk of epithelial ovarian cancer remains inconclusive. Many studies evaluating this association have had insufficient statistical power to detect modest effects, particularly for histological subtypes of
OBJECTIVE
Obesity is an increasing health problem that is reported to influence chemotherapy dosing. The extent to which this occurs and whether this affects outcomes in ovarian cancer was unclear. To describe chemotherapy dosing practices in normal, overweight and obese patients treated for FIGO
OBJECTIVE
Epidemiologic data suggest that aberrant androgen homeostasis may promote aggressive epithelial ovarian cancer biology. Hyperandrogenism results from both obesity and expression of polymorphic androgen receptor (AR) allelotypes harboring short cytosine-adenine-guanine (CAG) repeat
Obesity is a known generator of chronic inflammation but has an uncertain role in ovarian carcinogenesis and survival. Pro-inflammatory cytokines have previously been associated with poor outcomes. Given the established links, we sought to determine whether obesity and pro-inflammatory cytokines
Objectives: To determine whether neoadjuvant chemotherapy (NACT) disproportionately benefits obese patients.
Methods: Data were collected from stage IIIC-IV ovarian cancer
OBJECTIVE
To examine the effect of body mass index (BMI) on postoperative 30-day morbidity and mortality after surgery for ovarian cancer (OC).
METHODS
Patients with OC were identified from the American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2011. Women were
OBJECTIVE
To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level.
METHODS
We assessed current weight, weight at age 18, and adult weight change in relation to ovarian cancer risk among 109,445 participants in the Nurses' Health Study.
A morbidly obese woman with a huge ovarian tumor was scheduled to undergo tumor resection under general anesthesia. Under slight sedation with midazolam and fentanyl, a tracheal tube was inserted smoothly using Pentax-AWS Airway Scope, and general anesthesia was thereafter maintained by sevoflurane.
OBJECTIVE
In this study, we evaluated the effect of body mass index (BMI) on the quality of life of ovarian cancer survivors.
METHODS
Women diagnosed with ovarian cancer at the Royal Cornwall Hospital Trust between January 2008 and May 2013 were identified. Ovarian cancer survivors were invited to
Data from a population-based case-control study conducted in Washington State and Utah were used to assess whether obesity is associated with an altered risk of epithelial ovarian cancer. Quetelet index, defined as weight (kg) at age 30 years divided by height (m) squared, was calculated for each
OBJECTIVE
Cigarette smoking is the leading cause of morbidity and mortality worldwide. We investigated the association between smoking behavior and genetic variations in the D2 dopamine receptor (DRD2), which mediates nicotine dependence. To assess the specificity of genetic effects, we also
OBJECTIVE
To evaluate the effect of body mass index on the surgical outcomes in ovarian cancer patients. In addition, we performed a systematic review to compare our outcomes with the current literature.
METHODS
Retrospective cohort study and a systematic review of the
BACKGROUND
Adult body size is related to ovarian cancer risks, but size in childhood may also influence risks. We investigated if childhood body mass index (BMI; kg/m2), height, and growth patterns were associated with ovarian cancer overall and by histologic subtypes, including effects of
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved