pancratistatin/neoplasms

The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin, as well as a method for their preparation and their use in cancer chemotherapy. Narciclasine 1 is part of the alkaloids of the Amaryllidaceae family. Isolated from narcissus bulbs, its cytotoxic properties

The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin, as well as a method for their preparation and their use in cancer chemotherapy. Narciclasine 1 is part of the alkaloids of the Amaryllidaceae family. Isolated from narcissus bulbs, its cytotoxic properties

FIELD The present application relates to novel C-1 analogs of pancratistatin and 7-deoxypancratistatin and to processes for their preparation. The application further relates to pharmaceutical compositions containing the novel analogs and to uses of the analogs. BACKGROUND Pacratistatin (1) and

INTRODUCTION The present invention relates generally to a new antineoplastic substance denominated "pancratistatin", its synthetic counterpart and pharmaceutically acceptable derivatives thereof. The invention further comprises methods for obtaining pancratistatin and 7-deoxynarciclasine, procedures

INTRODUCTION The present invention relates generally to a new antineoplastic substance denominated "pancratistatin", its synthetic counterpart and pharmaceutically acceptable derivatives thereof. The invention further comprises methods for obtaining pancratistatin and 7-deoxynarciclasine,