para aminobenzoic acid paba/hypersensitivity

BACKGROUND Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction that occurs when a previously photosensitized exogenous agent comes into contact with UV radiation. Currently, there are no studies profiling photoallergic reactions in Canada. Because the photoallergen profile changes

Dendritic cells (DCs) are known to internalize, process, and present low-molecular-weight chemicals to T cells in the course of the sensitization and elicitation phase of allergic contact dermatitis. Thus, DCs may be involved in metabolic activation and detoxification of haptens and thereby

Xenobiotic metabolizing enzymes like cytochrome P450s and N-acetyltransferase are expressed in keratinocytes and professional antigen-presenting cells. Thus, biotransformation of chemicals applied to the skin can be relevant for their potential to cause skin toxicity and immune responses like

BACKGROUND Para aminobenzoic acid (PABA) derivatives and cinnamate are chemical sunscreens that protect against UVB (290 to 320 nm). They may occasionally produce contact and photocontact sensitization. OBJECTIVE To report a sensitization to octyl-dimethyl-PABA and photosensitization to

BACKGROUND Rising use of sunscreen products has led to increased reporting of adverse reactions to sunscreens. OBJECTIVE To investigate possible photoallergic reactions in patients who identified themselves as "being allergic" to sunscreens. METHODS Patients filled out questionnaires about types of

The brachial plexus is a nerve network that supplies the upper extremity. It is formed by C5-T1. It exits the cervical spine and travels between the anterior and middle scalene muscles and then travels distally around the axillary artery. The space between the scalene muscles is called the