piperidine/infarction

BACKGROUND OF THE INVENTION The present invention relates to novel piperidine derivatives, their manufacture and use as medicaments. SUMMARY OF THE INVENTION The subject invention provides compounds of the formula: ##STR1## wherein R.sup.1 is naphthyl or naphthyl substituted by one to three C.sub.1

CROSS REFERENCE TO RELATED APPLICATIONS This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/JP2004/013768, filed Sep. 21, 2004, which claims priority under 35 U.S.C. .sctn. 119 from Japanese Application No. JP2003-330758, filed Sep. 22,

TECHNICAL FIELD The present invention relates to a novel piperidine derivative, to a histamine-H3 receptor antagonist containing the novel piperidine derivative as an active ingredient thereof, and to a preventive or remedy for metabolic system diseases, circulatory system diseases, central or

PRIORITY TO RELATED APPLICATION(S) This application claims the benefit of European Patent Application No 11156587.5, filed Mar. 2, 2011, which is hereby incorporated by reference in its entirety. BACKGROUND OF THE INVENTION Alzheimer's disease (AD) is the most common cause of dementia in later life.

PRIORITY TO RELATED APPLICATION(S) This application claims the benefit of European Patent Application No. 10153843.7, filed Feb. 17, 2010, which is hereby incorporated by reference in its entirety. BACKGROUND OF THE INVENTION Alzheimer's disease (AD) is the most common cause of dementia in later

The present invention relates to compounds of formula ##STR00002## hetaryl is a five membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N; R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, S-lower alkyl substituted by halogen or

BACKGROUND OF THE INVENTION The present invention relates to novel piperidine derivatives, their manufacture and use as medicaments. SUMMARY OF THE INVENTION The subject invention provides compounds of the formula: ##STR2## wherein R.sup.1 is a) --(CH.sub.2).sub.k --N(R.sup.3,R.sup.4), wherein k is

The present invention relates to a compound of formula ##STR00002## wherein HetAr is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R.sup.1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, or lower alkoxy; R.sup.2 is

The invention relates to piperidine derivatives of the formula I ##STR2## in which X is 0, NR.sup.1, S or (CH.sub.2).sub.n, Y is CH, Z is CH, where Y and Z together can also be C.dbd.C, R.sup.1, R.sup.2 and R3 each independently of one another are H or A, R.sup.4 is H, Hal, A or OA, A is alkyl

This invention relates to a series of N-amidinopiperidine and benzamidine derivatives, which are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis,