psoriasis/phosphatase

INCORPORATION OF SEQUENCE LISTING The contents of the text file named "28856-502C02US_ST25.txt", which was created on Sep. 22, 2010 and is 3 KB in size, are hereby incorporated by reference in their entirety. BACKGROUND OF THE INVENTION Protein kinases are a large class of enzymes which catalyze the

BACKGROUND OF THE INVENTION Protein kinases are a large class of enzymes which catalyze the transfer of the .gamma.-phosphate from ATP to the hydroxyl group on the side chain of Ser/Thr or Tyr in proteins and peptides and are intimately involved in the control of various important cell functions,

FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to novel phosphotetrahydropyran compounds, primarily derivatives of mannose-6-phosphate, and their use in treating diseases or disorders that are mediated at least in part by T lymphocyte emigration from

FIELD OF THE INVENTION This invention relates to compounds which are inhibitors of protein tyrosine phosphatases (PTPases), which are useful for the management, treatment, control, or adjunct treatment of diseases caused by over-activity of PTPases. BACKGROUND OF THE INVENTION The process of protein

FIELD OF THE INVENTION This invention relates to compounds which are inhibitors of protein tyrosine phosphatases (PTPases), which are useful for the management, treatment, control, or adjunct treatment of diseases caused by over-activity of PTPases. BACKGROUND OF THE INVENTION The process of protein