During the prenatal evaluation, IMA and cytokine values in amniotic fluid will be compared in cases with down syndrome and normal karyotype.

Down Syndrome

Prenatal Stress

Cytokines

amniosyntesis

Karadeniz Technical Universty Medical School

The Role of Amniotic Fluid Biochemical Markers for Down Syndrome Diagnosis

The IMA levels in our study group was higher than control group.

Suleyman Guven

professor

Karadeniz Technical University

All drugs will be administered via intra-arterial (brachial artery) infusion, and the dosages below will be administered two times: once before administration of Vitamin B6 (pyridoxine) and once following administration of the Vitamin B6 (pyridoxine) loading dose.
Adenosine Triphosphate: 1.25, 2.5, 5, and 10 μg/dl forearm volume/min for 3 minutes each.
Acetylcholine: 1, 4, 8, and 16 μg/dl forearm volume/min for 3 minutes each.
Sodium Nitroprusside: 0.25, 0.5, 1, and 2 μg/dl forearm volume/min for 3 minutes each.
Vitamin B6 (pyridoxine): up to 200 mg of pyridoxine will be infused over 20 minutes. A maintenance dose of 2.5 mg/min may be used throughout the remainder of the protocol.
Pyridoxal-5-Phosphate (PLP) may be used as an alternative blocker instead of pyridoxine. It will be infused at doses up to 200 µg/dl forearm volume/min.

All drugs will be administered via intra-arterial (brachial artery) infusion, and the dosages below will be administered two times: once before administration of Vitamin B6 (pyridoxine) and once following administration of the Vitamin B6 (pyridoxine) loading dose.
Adenosine Triphosphate: 1.25, 2.5, 5, and 10 μg/dl forearm volume/min for 3 minutes each.
Adenosine Diphosphate: 20, 40, 80, and 160 μg/dl forearm volume/min for 3 minutes each.
Adenosine Monophosphate: 25, 50, 100, and 200 μg/dl forearm volume/min for 3 minutes each.
Vitamin B6 (pyridoxine): up to 200 mg of pyridoxine will be infused over 20 minutes. A maintenance dose of 2.5 mg/min may be used throughout the remainder of the protocol.
Pyridoxal-5-Phosphate (PLP) may be used as an alternative blocker instead of pyridoxine. It will be infused at doses up to 200 µg/dl forearm volume/min.

All drugs will be administered via intra-arterial (brachial artery) infusion, and the dosages below will be administered two times: once before administration of Vitamin B6 (pyridoxine) and once following administration of the Vitamin B6 (pyridoxine) loading dose.
Adenosine Triphosphate: 1.25, 2.5, 5, and 10 μg/dl forearm volume/min for 3 minutes each.
Uridine Triphosphate: 1.25, 2.5, 5, and 10 μg/dl forearm volume/min for 3 minutes each.
Adenosine: 3.125, 6.25, 12.5, and 25 μg/dl forearm volume/min for 3 minutes each.
Vitamin B6 (pyridoxine): up to 200 mg of pyridoxine will be infused over 20 minutes. A maintenance dose of 2.5 mg/min may be used throughout the remainder of the protocol.
Pyridoxal-5-Phosphate (PLP) may be used as an alternative blocker instead of pyridoxine. It will be infused at doses up to 200 µg/dl forearm volume/min.

Receptor Blockade

Adenosine Triphosphate

Acetylcholine

Sodium Nitroprusside

Adenosine Diphosphate

Adenosine Monophosphate

Uridine Triphosphate

Adenosine

Vitamin B 6

Pyridoxal 5'-Phosphate

Human Performance and Clinical Research Laboratory

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

Vascular conductance is an index of vascular tone through which vasodilation can be determined. Vascular conductance is calculated by measuring blood flow in response to infusion of a vasodilator and accounting for blood pressure. Thus, the change in blood flow is due to a change in vascular conductance.

Frank Dinenno

Professor

Colorado State University

Participants will be assigned to one of three arms of the study. The arms of the study are based on the vasodilators being tested in order to determine the effect of pyridoxine or PLP on vasodilation in response to intra-arterial administration of the vasodilators.

pyridoxine/hypoxia

The Role of Amniotic Fluid Biochemical Markers for Down Syndrome Diagnosis

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

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