saikogenin f/bupleurum

The corticosterone secretion-inducing activities of saikosaponin a, saikosaponin c and saikosaponin d, isolated from the root of Bupleurum falcatum L., and 27 metabolites formed in the murine alimentary tract were studied in mice. Serum corticosterone was determined by high-performance liquid

Five saikosaponins and two saikosapogenins were isolated from the roots of Bupleurum smithii var. parvifolium by column chromatography, preparative-TLC and HPLC, and identified as saikosaponin a, saikosaponin d, saikosaponin b2, saikosaponin b4, chikusaikoside I, saikogenin F and saikogenin G on the

Extracts of the root of B. fruticosum L. showed in a biological screening hemolytical activity, hepatoprotective and phagocytosis stimulating effects, and a specific inhibitory activity of leucine aminopeptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation