saikosaponin a/seizures

Saikosaponin a (SSa), a main constituent of the Chinese herb Bupleurum chinense DC., has been demonstrated to have antiepileptic activity. Recent studies have shown that SSa could inhibit NMDA receptor current and persistent sodium current. However, the effects of SSa on potassium (K(+)) currents

OBJECTIVE To investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats. METHODS Acute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the

OBJECTIVE Saikosaponin a (SSa), which is one major bioactive compound isolated from radix bupleuri, has been demonstrated to exhibit the properties of anticonvulsant and antiepileptic in few reports. This study aims to clarify the molecular mechanism by which SSa protects against pentylenetetrazol

UNASSIGNED Chronic temporal lobe epilepsy (cTLE) is the most common intractable epilepsy. Recent studies have shown that saikosaponin A (SSa) could inhibit epileptiform discharges induced by 4 action potentials and selectively increase the transient inactivating K+ currents (IA). However, the