Celiac Disease in Children

Erdes Svetlana

Population Study of the Prevalence of Celiac Disease and Other Gluten-dependent Disorders in Children and Adolescents

Study of the Prevalence of Gluten-dependent Diseases in the Russian Population and the Development of New Biotechnological Approaches to Obtain Gluten-free Products

Questionnaire by specially developed questionnaire. A structured questionnaire was used to collect data on symptoms and signs that are known to be associated with celiac disease. Each of the following statements begin with "Does your child have ...? " Scoring: Never=1; Seldom= 2; Frequent=3; A Lot=4; Don't Know=0; No=1; Yes=2 If the total score was 25 or more, then this respondent belongs to the high risk group for the development of celiac disease.

Serological and genetic testing in the laboratory. Screening for celiac disease for suspected celiac disease carried out by testing in an independent laboratory serological examinations (total IgA, AT to tissue transglutaminase IgA, AT to tissue transglutaminase IgG, AT to endomysium IgA); genetic screening - HLA-DQ2 / DQ8; IgE (wheat flour, F4).

The local ethics committee does not allow. But upon official request can provide.

I.M. Sechenov First Moscow State Medical University

Flour mills workers exposed to health hazards

Occupational Exposure

Pulmonary Function tests using Spirometry. It will show following indices of ventilatory functions: Forced vital capacity (FVC), Forced expiratory volume in the 1st second (FEV1) and Forced expiratory volume in the 1st second as a percentage of the Forced vital capacity (FEV1/FVC %).

Pulmonary function test

Assiut University

Occupational Health Hazards Among Flour Mills Workers

Occupational Health Hazards Among Flour Mills Workers And Effect Of Smoking Cessation Program On Smokers, Assiut

Ayah Atef Alkarn

Principal investigator

Introduced to the study by a dietitian.
Receive general information about healthy food choices (according to the Swedish National Food Agency's recommendations for the general public).
Be told not not to eat any dietary supplements, though no other dietary restrictions will be given.
Called one time during the study and perform a 24-hour recall.
The intervention continues until the day before the surgery (at least 6 weeks).
The patients in the experimental group will be given a package containing food with a high amount of phytoestrogens.

Introduced to the study by a dietitian.
Receive general information about healthy food choices (according to the Swedish National Food Agency's recommendations for the general public).
Be told not not to eat any dietary supplements, though no other dietary restrictions will be given.
Called one time during the study and perform a 24-hour recall.
The intervention continues until the day before the surgery (at least 6 weeks).

Prostate Cancer

The patients will be given a package containing food with a high amount of phytoestrogens (≥100 mg isoflavonoids and ≥100 mg lignans) that are to be consumed daily. The food-package contains 30 grams of flaxseed, 25 grams of roasted soybeans and 50 grams of frozen green edamame beans to be consumed daily.

Phytoestrogen-rich foods

Sahlgrenska University Hospital

Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation?

Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation? A Randomized Study (PRODICA)

Ki-67 is measured in tumor cells which are obtained from specimens from the prostate.

Maria Hedelin

P.hd, nutritionist

Sahlgrenska University Hospital, Sweden

Göteborg University

Whole-grain rye, high lignan Whole-grain rye products for 8 weeks, then a wash-out period of 8 weeks, and then whole-grain wheat products for 8 weeks

Whole-grain wheat, low lignan Whole-grain wheat products for 8 weeks, then a wash-out period of 8 weeks, and then whole-grain rye products for 8 weeks

Metabolic Syndrome

Overweight

Central Obesity

Impaired Glucose Tolerance

Intervention week 1-8: 50 g rolled rye + 50 g puffs + 4 pieces of crisp bread + 70 g pasta. Additionally for intervention week 4-8: 4 lignan capsules per day

Whole-grain rye, high lignan

Intervention week 1-8: 100 g puffs + 4 pieces of crisp bread + 70 g pasta.

Whole-grain wheat, low lignan

Paediatric Research Facility; The Children's Hospital at Uppsala University Hospital

Effects of Lignan-rich Diet on Cardiometabolic Risk Factors

Dr. Rikard Landberg

Associate professor, Head of Unit Food and Health, Department of Food Science, Swedish University of Agricultural Sciences (SLU)

Swedish University of Agricultural Sciences

Prescriptions: Vigorous exercise (average 65-70% of maximal oxygen consumption) minimum 3 times 45 minutes per week according to customized endurance training programs.
Restrictions: None.

Exercise

Prescriptions: Minimum 170-180g of whole grain rye intake per day. Restrictions: None.

Whole grain rye

Recommendations on a health-promoting, energy restricted diet according to Danish Nutrition Recommendations and encouraged to walk at least 10,000 steps every day.

Recommendations

Aarhus University, Institute of Sport Science

Counseling Center, Danish Cancer Society

Aarhus University Hospital Skejby

Danish Cancer Society

Feasibility Study on a Nordic Lifestyle Intervention Trial Among Men With Prostate Cancer

Feasibility Study on a Nordic Lifestyle Intervention Trial Investigating the Effect of Vigorous Activity and Intake of Whole Grain Rye on Cancer Progression, Insulin Sensitivity and Inflammation Among Men With Early Stage Prostate Cancer.

Feasibility of an intervention trial is evaluated among Danish men with early stage prostate cancer. Enrollment of participants, possible for this particular type of trial among the particular patient group? Compliance with intervention, obtainable for intervention participants with the tools planned (counseling sessions, exercise programs, supply of rye products, sphygmographs and pedometers)? Does the design minimize drop out? Is the schedule for monitoring, counseling, testing and collection of biological samples efficient and feasible for the research team and for the participants?

PSA is measured at baseline and 3, 6 and 12 months after baseline among all participants. Prostate biopsies are made at baseline and 6 months after baseline among all participants.

Oral glucoce tolerance test is made among all participants at baseline, and 3, 6 and 12 months after baseline.
C peptide levels will be measured in 24h urine samples the following year after the intervention. The urine samples are collected at baseline, and 3, 6 and 12 months after baseline from all participants.

Life quality is evaluated by questionnaires answered by all participants at baseline, and 6 and 12 months after baseline.

The following measurements are made at baseline, and 3, 6 and 12 months after baseline among all participants: Bioimpedance, skin fold analysis, waist and hip circumference, weight and height, and blood pressure.

CRP is measured among all participants at baseline, and 3, 6 and 12 months after baseline.

secale africanum/neoplasms

Population Study of the Prevalence of Celiac Disease and Other Gluten-dependent Disorders in Children and Adolescents

Occupational Health Hazards Among Flour Mills Workers

Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation?

Effects of Lignan-rich Diet on Cardiometabolic Risk Factors

Feasibility Study on a Nordic Lifestyle Intervention Trial Among Men With Prostate Cancer

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