A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and non-irritating, while stabilizing and increasing the bioavailability of the drug. The invention also provides compositions that enhance absorption of drugs via the oral, ocular, nasal, nasolacrimal, inhalation or pulmonary, oral cavity (sublingual or Buccal cell) or CSF delivery route of a patient, including but not limited to insulin, glucagon and exendin-4.

Aegis Therapeutics, LLC.

Pharmaceutical composition including alkyl glycoside and an anti-seizure agent

A method of treating a brain disorder by heat transfer from brain tissue comprising the steps of surgically cutting a heat transfer aperture into a patient's skull, thereby exposing a predetermined portion of patient's brain; surgically implanting into said heat transfer aperture a heat pump having one or more electrical sensor elements and one or more temperature sensor elements; surgically implanting a heat transfer management unit in a body cavity of said patient such that a micro controller of the heat transfer management unit is connected to one or more activity sensor elements and one or more temperature sensor elements contacting brain tissue and connecting the heat transfer management unit to said heat pump via a lead bundle. Optionally, the heat transfer unit may be located external to the patient's body. Responsive to signals from one or more activity or temperature sensor elements, mathematical algorithms of the heat transfer management unit determine abnormal brain activity, causing the heat pump to remove heat from the brain tissue into a heat sink, thereby cooling the predetermined portion of the patient's brain. This technique utilizes acute hypothermia by means of a Peltier cooler or similar device to cool the brain temperature to reduce or prevent seizure initiation and/or propagation. The method may be used in association with brain stimulation and/or drug application to acutely avoid the occurrence of a seizure episode.

The Johns Hopkins University

Technique for using heat flow management to treat brain disorders

Custodial protective structure for severely handicapped children subject to involuntary spastic responses is disclosed. A body support, formed from an elastically resilient material such as foamed rubber or vinyl, provides a body mold cavity establishing relaxed positional support and provides limited yielding in the event of seizure. A stabilizer holds the body support to limit longitudinal yielding and prevent asymmetric twisting of the body support while allowing access for handling and therapy; the stabilizer framework facilitates canting of the structure or mounting for swinging movement.

seizures/dental caries

Pharmaceutical composition including alkyl glycoside and an anti-seizure agent

Technique for using heat flow management to treat brain disorders

Positioning structure for handicapped person

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