single umbilical artery/hypoxia

Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was

Key points: Fetal growth restriction induces a hemodynamic response which aims to maintain blood flow to vital organs such as the brain, in the face of chronic hypoxemia Maternal sildenafil treatment impairs the hypoxemia-driven

OBJECTIVE To determine whether activin A concentrations are altered in chronic fetal hypoxemia and intrauterine fetal growth restriction (IUGR). METHODS In vivo animal experimental model. METHODS Department of Physiology, Monash University. METHODS Chronically catherised fetal sheep in late

Among 62 cases with single umbilical artery and 305 with velamentous insertion of the umbilical cord, we found a high incidence of congenital malformations in both groups, highest in the SUA-group. No organ system seemed to be more affected than the others. In both groups there was a high incidence

OBJECTIVE In the present study we examined the effects of low-dose endotoxin (lipopolysaccharides, LPS) on continuously recorded umbilical blood flow. METHODS Twenty fetal sheep were catheterized at a gestational age of 107 +/- 1 days. A flow probe was placed around either the common umbilical

Chorangiosis is microscopically designated as more than ten terminal capillaries within the villous stroma of the placenta and is mostly related to chronic fetal hypoxia. However, the histogenetic relationship between increased number of terminal villous capillaries and chronic hypoxia has not yet

A study was undertaken to investigate the applicability of the arteriovenous mode of perfusion for partial support of neonatal respiration. Perigestational lambs, delivered by cesarean section, served as the animal model of respiratory distress. Arteriovenous flow was accomplished between a single

The result of pathological analysis of 76 placentae and their appendices from clinically diagnosed fetal distress in year 1985-1989 is here presented. The findings could be classified into 4 groups; lesions due to disturbance of maternal blood flow and villous ischemia or hypoxia; retardation of

Oxidative stress arising from suboptimal placental function contributes to a multitude of pathologies in infants compromised by fetal growth restriction (FGR). FGR infants are at high risk for respiratory dysfunction after birth and poor long-term lung function. Our objective was to investigate the

Chronic moderate hypoxia, such as occurs in fetal growth restriction (FGR) during gestation, compromises the blood-brain barrier (BBB) and results in structural abnormalities of the cerebral vasculature. We have previously determined the neuroprotective and antioxidant effects of maternal

Fetal growth restriction (FGR) complicates 5-10% of pregnancies and is associated with increased risks of perinatal morbidity and mortality. The development of cerebellar neuropathology in utero, in response to chronic fetal hypoxia, and over the period of high risk for preterm birth, has not

The purpose of this study was to compare specific fetal, maternal, and placental factors, including neonatal morbidity and mortality, in infants with umbilical cords (UCs) of normal length to the same factors in infants with excessively long umbilical cords (ELUCs). We performed an 18-year