stuttering/hypoxia

BACKGROUND In this study the authors analyse, clinically, dysphemia (DP) and acquired stuttering (AS). AIMS. The aim of this study was to evaluate whether AS is a variant of DP or whether it is an entity that shares a common element: stuttered speech. METHODS The authors studied 13 patients with AS

Priapism is a rare condition that involves persistent penile erection for greater than 4 h. Distinct variants exist, each with unique characteristics. Ischemic priapism is a painful medical emergency that may occur as a result of veno-occlusion leading to hypoxia and tissue death. Recurrent bouts of

OBJECTIVE We identify whether tachyphylaxis and priapism effects of sildenafil are related to regulation of phosphodiesterase-5 (PDE-5) expression. METHODS Cavernous smooth muscle cells (CSMCs) were isolated from young rats and treated with 0, 1, 10 and 25 microM sildenafil with or without 100

Phosphodiesterase 5 (PDE5) has been identified in many species. The three isoforms, PDE5A1, PDE5A2, and PDE5A3, differ only in their N-terminal sequence. PDE5A1 and PDE5A2 are ubiquitous, but PDE5A3 is specific to smooth muscle. The initial three exons (A1-A3-A2) of PDE5A, located on chromosome

BACKGROUND There are three different types of priapism: low-flow, ischemic, anoxic or veno-occlusive priapism; high-flow, arterial or nonischemic priapism; and recurrent or stuttering priapism. OBJECTIVE To provide recommendations/guidelines concerning state-of-the-art knowledge for the diagnosis