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FIELD OF THE INVENTION
The invention relates to pseudo-primycin complexes and to components and to acid addition salts thereof as well as to a process for the preparation of same.
The invention further relates to pharmaceutical compositions containing said pseudo-primycin complex and/or any
The invention relates to novel crystalline cephem acid addition salts which are distinguished by particularly low solubility, processes for their preparation and their use as pharmaceuticals. ##STR2##
German Patent Applications DE 3 248 281 (U.S. Pat. No. 4,609,653) (for n=1) and DE 3 706 020 (U.S.
The invention relates to crystalline, enterally absorbable salts of .alpha.-(2,2-dimethylpropanoyloxy)ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-methoxymethyl-3 -cephem-4-carboxylate of the formula I ##STR2## and a process for their preparation.
Many clinically relevant
BACKGROUND OF THE INVENTION
The invention relates to addition products between .alpha.-keto-aldehydes and secondary amines
.alpha.-KETO-ALDEHYDES ARE WELL KNOWN AND USUALLY ARE PREPARED THROUGH OXIDATION (Riley, H. L., Morley, J. F., and Friend, N.A.C.: J.Chem.Soc. 1932.1875; Rabjohn, N.: in Organic
This invention relates to a novel bis-(meta-amidinophenoxy)-compound and a pharmacologically acceptable acid addition salt thereof which is represented by the general formula: ##STR1## wherein A represents a chain residue selected from the group consisting of ##STR2## --CH.sub.2
This invention relates to a novel bis-(meta-amidinophenoxy)-compound and a pharmacologically acceptable acid addition salt thereof which is represented by the general formula: ##STR1## wherein A represents a chain residue selected from the group consisting of ##STR2## and --(CH.sub.2).sub.m --, in
DESCRIPTION
The invention relates to crystallized acid-addition salts of an antibiotic of the formula Ia or Ib and the hydrates thereof, and a process for the preparation of these compounds. ##STR2## In the general formula I, X.sup.- denotes the anion of a monobasic acid, and
Y.sup.2- denotes the
The invention relates to crystalline, enterally absorbable salts of the diastereomers of 1-(2,2-dimethylpropionyloxy)-ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-methoxymethyl-3 -cephem-4-carboxylate of the formula I ##STR2## and to processes for their preparation.
Esters of
The invention relates to crystalline, enterally absorbable salts of the diastereomers of 1-(2,2-dimethylpropionyloxy)-ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-methoxymethyl-3 -cephem-4-carboxylate of the formula I ##STR2## and to processes for their preparation.
Esters of
FIELD OF THE INVENTION
The invention relates to pseudo-primycin complexes and to components and to acid addition salts thereof as well as to a process for the preparation of same.
The invention further relates to pharmaceutical compositions containing said pseudo-primycin complex and/or any
EXAMPLE 1
4-O-Acetyl-1-Deoxy-1-(Pyridyl-2-thio)-.alpha.- and -.beta.-L-Cladinoside
(a) L-Cladinose
Erythromycin A (Merck Index, 10th Edition Entry No. 3624) (50g) was dissolved in 1N aqueous hydrochloric acid (70 mL) and water (500 mL) and the mixture subjected to liquid-liquid extraction using
This invention relates to compounds of the formula: ##STR2## wherein R is hydrogen, lower alkyl, aryl, halogen, trifluoromethyl, lower alkoxy, aryloxy, di(lower alkyl)amino and ##STR3## and R.sup.1 is a monocyclic 5- or 6-membered heterocyclic containing a hetero atom such as sulfur, oxygen, or
This invention is concerned with substituted chromene derivatives of the general formula ##STR2##
in which R.sup.1 represents alkyl or cycloalkylalkyl, R.sup.2 and R.sup.3 each independently represent alkyl or cycloalkyl or taken together with the adjacent carbon atom represent a saturated 3- to
CROSS-REFERENCE TO RELATED APPLICATION
This application claims priority to and the benefit of Korean Patent Application No. 10-2014-0177329, filed on Dec. 10, 2014, Korean Patent Application No. 10-2014-0177352, filed on Dec. 10, 2014 and International Patent Application No. PCT/KR2015/013521, filed
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to new chemical compounds which are of value as antibacterial agents. More particularly, it relates to novel bis esters of hydroxymethyl carbonate, HOCH.sub.2 OCOOCH.sub.2 OH, in which one hydroxy group is esterified with