suma/tyrosine

INTRODUCTION 1. Technical Field The field of this invention relates to novel tyrosine kinases. 2. Background The growth and differentiation of hematopoietic cells depends upon interaction with specific cells and molecules in the environment. The delivery of the appropriate signal can come directly

CROSS REFERENCES TO RELATED APPLICATIONS The present application claims priority to Japanese Priority Patent Application JP 2010-016675 filed in the Japan Patent Office on Jan. 28, 2010, the entire contents of which are hereby incorporated by reference. BACKGROUND The present application relates to

FIELD OF THE INVENTION Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. BACKGROUND OF THE INVENTION Bruton's

FIELD OF THE INVENTION Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. BACKGROUND OF THE INVENTION Bruton's

FIELD OF INVENTION The present invention generally relates to antibodies which are reactive with Tie, a receptor tyrosine kinase found in various endothelial cells and in certain tumor cell populations. In addition, the present invention relates to methods for making such antibodies and to methods

BACKGROUND OF THE INVENTION Technical Field The present disclosure relates to compounds having a tyrosine-based structure with prenyl group substitution and bearing properties for abrogating TRAIL resistance. A method for producing the compounds, and a pharmaceutical composition comprising one or

BACKGROUND OF THE INVENTION Technical Field The present disclosure relates to compounds having a tyrosine-based structure with prenyl group substitution and bearing properties for abrogating TRAIL resistance. A method for producing the compounds, and a pharmaceutical composition comprising one or

BACKGROUND OF THE INVENTION 1. Technical Field This invention relates to a method of effervescent formulation for the promotion of tyrosine or a tyrosine precursor solubility, absorption and accuracy of measure for oral supplementation and its use with vitamin, mineral and nutritional

BACKGROUND OF THE INVENTION 1. Technical Field The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I ##STR00002## wherein R.sup.1 and R.sup.2 independently denote C.sub.1-3-alkyl groups and X.sup.- denotes

TECHNICAL FIELD The present invention relates to: a DNA encoding a polypeptide which modulates the activity of a muscle-specific tyrosine kinase; a vector including the DNA; a transformant having the vector introduced therein; a polypeptide encoded by the DNA; an antibody that binds to the

BACKGROUND 1. Field of the Invention The invention relates to nucleoside phosphonate compounds and methods of synthesis, isomerization and uses thereof. 2. Related Art Acyclic nucleoside phosphonates (ANPs) are broad spectrum antiviral agents that are highly potent against orthopox viruses,

FIELD OF THE INVENTION The present invention relates to a method of producing (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active phenylserine and its halogen substitution products, which are represented by Formula (2), using an enzyme or microorganism. The present

BACKGROUND Glivec and Iressa are small-molecule tyrosine kinase inhibitors used in earlier clinical tumor therapy and have good clinical effect, which greatly stimulates interests of global leading pharmaceutical companies and research institutions in the study of such targets. Therefore,

This application is the National Stage of Application No. PCT/EP2006/046543, filed on Dec. 6, 2006, which claims benefit under 35 U.S.C. .sctn.119(a-d) of U.S. Provisional Application No. 60/748,491, filed Dec. 8, 2005, the contents of which are incorporated herein by reference in their

BACKGROUND OF THE INVENTION Tyrosine kinases are a class of enzymes that catalyze the transfer of the terminal phosphate of adenosine triphosphate (ATP) to tyrosine residues in protein substrates. Tyrosine kinases are believed, by way of substrate phosphorylation, to play critical roles in signal