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A double-blind trial of the effect of droperidol on the incidence of nausea and vomiting in patients using patient-controlled analgesia was carried out in 60 healthy women undergoing abdominal hysterectomy. After a standard anaesthetic including droperidol 2.5 mg as a prophylactic antiemetic,
BACKGROUND
In this study, using a dose-ranging design, we examined the effects of clonidine with 0.125% bupivacaine on the duration of post-operative analgesia in caudal anaesthesia in children.
METHODS
We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children,
OBJECTIVE
To evaluate liraglutide as an antidiabetic agent.
METHODS
The pertinent English-language medical literature was reviewed for the period from 1985 to April 2010 with use of data from MEDLINE.
RESULTS
Liraglutide is a glucagonlike peptide-1 receptor analogue that stimulates insulin
OBJECTIVE
To present an evidence-based evaluation of the antidiabetic drug exenatide.
METHODS
The English literature from 1965 to January 2006 was reviewed by using data sources from MED-LINE, endocrinology textbooks, and manual searching of cross-references from original articles and
Chemotherapy-induced nausea and vomiting is a challenging issue. Although aprepitant is sometimes used as a therapeutic option in patients receiving moderately emetogenic chemotherapy, the potential benefit of sequential addition of aprepitant to dexamethasone and a 5-hydroxytryptamine-3 (5-HT3)
OBJECTIVE
Postoperative nausea and vomiting after anesthesia is an distressing side effect. This study was undertaken to determine to what extent spinal opioids contribute to postoperative nausea and vomiting (PONV) and secondly to how effectively metoclopramide can reduce the incidence of PONV
Lignocaine has been shown to reduce the incidence of pain on injection of propofol. Metoclopramide, a weak local anaesthetic and commonly used antiemetic, was combined with propofol and the mixture compared, in a prospective, randomized trial, with a lignocaine-propofol combination. The incidence of
OBJECTIVE
We investigated whether aprepitant, a neurokinin-1 antagonist, could decrease chemotherapy-induced nausea and vomiting (CINV) following cisplatin, when a conventional anti-emetic regimen had failed.
METHODS
This was a prospective study (April 2011-April 2012) of patients with lung cancer,
BACKGROUND
This prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective Caesarean section.
METHODS
Sixty healthy parturients were randomly assigned to receive an initial dose of 90 mg of plain ropivacaine, or 90 mg of ropivacaine plus 10 or 20
BACKGROUND
So far only ropivacaine concentrations of 0.5 and 0.75% have been used for Caesarean section. This prospective double-blind trial evaluated the anaesthetic quality of ropivacaine 1% with and without sufentanil addition.
METHODS
Three groups of patients (n=20 each) scheduled for an
It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone, or
BACKGROUND
In a prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of adding meperidine 10 mg to intrathecal bupivacaine on the duration of early postoperative analgesia in 40 patients having elective Caesarean section under spinal
BACKGROUND
Fidaxomicin, a macrolide antibiotic, was the first medication for the management of Clostridium difficile infections (CDI) to be approved by the US Food and Drug Administration in more than 20 years.
OBJECTIVE
This article reviews published literature on fidaxomicin for management of CDI,
OBJECTIVE
To evaluate the antiemetic efficacy and safety of adding the dopamine antagonist prochlorperazine to the combination of granisetron and dexamethasone in the prevention of acute nausea and vomiting following high-dose cisplatin.
METHODS
Sixty patients receiving cisplatin (> or = 75 mg/m2)
BACKGROUND
The addition of a chemotherapy drug or drugs to an established regimen is one method used to increase the dose and intensity of treatment for metastatic breast cancer.
OBJECTIVE
To identify and review the randomised trial evidence in the first line management of women with metastatic