tabernaemontana pachysiphon/leukemia

In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors, conophylline, a vinca alkaloid isolated from the plant Ervatamia microphylla, was found to inhibit TNF-alpha-induced NF-kappaB activation. We studied the effect of conophylline on TNF-alpha-induced

Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of 2-deoxyglucose in K-ras-NRK cells. Conophylline inhibited the growth of K-ras-NRK cells, but this inhibition was

Fractionation of the sap of Tabernaemontana arborea, guided by cytotoxicity against the P-388 lymphocytic leukemia, yielded the known indole alkaloids voacangine, voacamine, and epivoacorine as the major cytotoxic constituents.