The present invention relates to a new taxane having the structure as in Formula I, and its analogs as depicted in Formula II and Formula III. The invention includes novel semi-synthetic and isolation methods for the preparation of these novel taxanes. Specifically, the present invention relates to the new taxane Canadensol isolated from plants of the Taxus genus in particular, Taxus canadensis. The present invention further relates to the use of these new taxanes as anticancer agents.

Institut National de la Recherche Scientifique

Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof

Taxol, an antineoplastic drug, has shown cytotoxic activity against numerous malignant tumors including: breast cancer, colon cancer, ovarian cancer, and skin cancer. Taxol is found in many species of yew including: slow-growing Taxus brevifolia and faster-growing Taxus media X Hicksii. Yew tree cuttings were cultured and the medium was extracted weekly, bi-weekly, and tri-weekly over a period of nine weeks. Taxol and other taxanes were separated through a multi-step procedure using hexane extractions, C-18 Sep Pak cartridges, and high performance liquid chromatography (HPLC). The concentration of the taxanes was then calculated. Taxol and other taxanes can continue to be transferred into a culture medium and extracted over a nine-week period. There is a higher yield when extracted weekly.

University of Portland

Transfer of taxol from yew tree cuttings into a culture medium over time

The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew tree Taxus wallichiana against human cancer cell lines grown in-vitro and subsequent identification of brevifoliol [1] as anticancer agent useful in the treatment of various types of cancer in humans ##STR00001##

taxus/抗癌药

Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof

Transfer of taxol from yew tree cuttings into a culture medium over time

Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor

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