tetrahydrothiophene/inflammation

Growth factors comprise a family of polypeptides with a manyfold of properties regulating for example cell proliferation and cell metabolism. As being multi-functional molecules, they may stimulate or inhibit cell proliferation as well as affect cell function depending on the type of the target

BACKGROUND OF THE INVENTION Platelet-activating factor (PAF) has recently been identified as an acetyl glyceryl ether phosphorylcholine (AGEPC), i.e., 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (Hanahan D. J., et al., J. Biol. Chem. 255:5514, 1980). Even before its chemical

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by

FIELD OF THE INVENTION This invention is in the area of compounds, pharmaceutical compositions and methods for the treatment of inflammatory, cardiovascular and immune disorders. The compounds and compositions of the present invention exhibit these biological activities by acting as PAF receptor

FIELD OF THE INVENTION This invention is in the area of compounds, pharmaceutical compositions and methods for the treatment of inflammatory, cardiovascular and immune disorders. The compounds and compositions of the present invention exhibit these biological activities by acting as PAF receptor

FIELD OF THE INVENTION This invention is in the area of compounds, pharmaceutical compositions and methods for the treatment of inflammatory, cardiovascular and immune disorders. The compounds and compositions of the present invention exhibit these biological activities by acting as PAF receptor

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by inhibiting the enzyme 5-lipoxygenase. BACKGROUND OF THE INVENTION Leukotrienes are potent

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by inhibiting the enzyme 5-lipoxygenase. BACKGROUND OF THE INVENTION Leukotrienes are potent

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by inhibiting the enzyme 5-lipoxygenase. BACKGROUND OF THE INVENTION Leukotrienes are potent

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by inhibiting the enzyme 5-lipoxygenase. BACKGROUND OF THE INVENTION Leukotrienes are potent

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by

FIELD OF THE INVENTION This invention is in the area of 2,5-disubstituted tetrahydrothiophenes, tetrahydrofurans, pyrrolidines and 1,3-disubstituted cyclopentanes. The compounds exhibit biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by

This invention is in the area of pharmaceutical compositions and methods for the treatment of inflammatory and immune disorders, and specifically provides novel compounds that reduce damage arising from an inflammatory or immune response. The compounds exhibits this biological activity by acting as

BACKGROUND OF THE INVENTION This invention is in the area of pharmaceutical compositions and methods for the treatment of inflammatory and immune disorders, and specifically provides novel compounds that reduce damage arising from an inflammatory or immune response. The compounds exhibit this