virilism/sarcoma

Effects of neonatal androgenization on 7,12-dimethylbenz[a]anthracene (DMBA)-induced endometrial carcinogenesis in Sprague-Dawley rats are studied. Testosterone propionate (1.25 mg) was injected subcutaneously into 110 2-day-old rats. At 8 weeks of age, a pellet containing 0.2 or 1mg DMBA was

An adrenal carcinosarcoma is reported in a 29-year-old female presenting with clinical signs of virilization. This is the first reported case of a functioning adrenal carcinosarcoma in the English language literature. The tumor measured 12.5 cm in greatest dimension, weighed 610 g, and consisted of

A single injection of testosterone propionate to newborn female CBA mice provoked earlier puberty and formation of permanent estrous in the majority of animals. This led to an abrupt reduction of the latent period and the increased incidence of 1,2-dimethylhydrazine-induced uterine sarcomas (90