Association Between Helicobacter Pylori and Inflammatory Bowel Disease
關鍵詞
抽象
描述
PATIENT AND METHOD :
observation Cross sectional study will be conducted at assuit university hospitals on all patients with inflammatory disease to detect the prevalence of helicobacter pylori among them .Then the examined patients will be divided in to two group receiving the same medication group A : inflammatory bowel disease patient with H.PYLORI group B: inflammatory bowel disease Patient without H.PYLORI longitudinal study will be conducted to both group to study the clinical outcomes in both group .
1. Thorough medical history and full clinical examination will be taken from all patient including
-Personal history focus on special habit especially smoking
-documented previous history for H.pylori eradication
- Onset and duration of inflammatory bowel disease
- current medication
- presence of any extra intestinal manifestation of Inflammatory bowel disease
- presence of any complications from Inflammatory bowel disease
2. Investigation :
-All patients with inflammatory bowel disease will be tested for presence or absence of H.PYLORI by histological examination of endoscopically biopsied gastric mucosa
-his to logical examination of colonic mucosal every 3 months
-complete blood count
-serum albumin
-c reactive protein, erythrocyte sedimentation rate (ESR).
-fecal calprotectin if possible
- assess the severity of among both group (A,B) every 3 month for 2years. ulcerative by Mayo Score/Ulcerative Colitis Disease Activity Index and Crohn's disease by Montreal classifications for Crohn's Disease .
Mayo Score/Ulcerative Colitis Disease Activity Stool frequency 0 = Normal 1 = 1-2 stools/day more than normal 2 = 3-4 stools/day more than normal 3 = 4 stools/day more than normal Rectal bleeding 0 = None 1 = Visible blood with stool less than half the time 2 = Visible blood with stool half of the time or more 3 = Passing blood alone Mucosal appearance at endoscopy 0 = Normal or inactive disease 1 = Mild disease (erythema, decreased vascular pattern, mild friability) 2 = Moderate disease (marked erythema, absent vascular pattern, friability, erosions) 3 = Severe disease (spontaneous bleeding, ulceration) Physician rating of disease activity 0 = Normal 1 = Mild 2 = Moderate 3 = Severe
日期
| 最後驗證: | 12/31/2018 |
| 首次提交: | 01/18/2019 |
| 提交的預估入學人數: | 01/24/2019 |
| 首次發布: | 01/28/2019 |
| 上次提交的更新: | 01/28/2019 |
| 最近更新發布: | 01/29/2019 |
| 實際學習開始日期: | 01/31/2019 |
| 預計主要完成日期: | 01/31/2019 |
| 預計完成日期: | 01/31/2021 |
狀況或疾病
相
手臂組
| 臂 | 干預/治療 |
|---|---|
| Group A Group A inflammatory bowel disease with helicobacter pylori infection | |
| Group B Inflammatory bowel disease without helicobacter pylori infection |
資格標準
| 有資格學習的性別 | All |
| 取樣方式 | Non-Probability Sample |
| 接受健康志願者 | 是 |
| 標準 | Inclusion Criteria: - all inflammatory bowel disease at assiut university will be included and examined in cross sectional study for detection of presence of H.pylori in one year 2019-2020 .then the examined patients will be divided in two group A ,B according to presence or absence of H pylori . Both group will be studied in cohort study for two years Exclusion Criteria: - -patients with history of administration of proton pump inhibitor or antibiotics with in eight weeks . - patients with history of recent upper gastrointestinal bleeding |
結果
主要結果指標
1. prevalance of H.pylori among patients with inflammatory bowel disease [One years]
2. Mayo score activity index among ulcerative colitis patients with H.pylori and without H.pylori [Two years]
3. Mucosal healing among inflammatory bowel disease with H.pylori and without H.pylori [1years]
