Acute-phase Response & Periodontal Treatment in Obese Patients
關鍵詞
抽象
描述
Periodontal treatment, consisting in both supra- and sub-gingival mechanical instrumentation of the root surface (scaling and root planing), will be performed by a single periodontist on obese patients with periodontitis.
The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment.
Treatment will be provided using both hand and ultrasonic instrumentation with fine tips.
FM-SRP patients will received treatment within 24 h. Q-SRP patients will received four quadrants sessions of periodontal treatment with an interval of 1 week between sessions.
Vital, endothelial function and blood inflammatory parameters will be evaluated at baseline, 24 hours after the first treatment and after 3 months. Periodontal parameters will be evaluated at baseline and after 3 months.
日期
| 最後驗證: | 04/30/2018 |
| 首次提交: | 03/07/2017 |
| 提交的預估入學人數: | 04/17/2017 |
| 首次發布: | 04/20/2017 |
| 上次提交的更新: | 04/30/2018 |
| 最近更新發布: | 05/01/2018 |
| 實際學習開始日期: | 05/31/2016 |
| 預計主要完成日期: | 05/31/2019 |
| 預計完成日期: | 12/31/2019 |
狀況或疾病
干預/治療
Procedure: Full mouth scaling and root planing
Procedure: Quadrant scaling and root planing
相
手臂組
| 臂 | 干預/治療 |
|---|---|
| Experimental: Full mouth scaling and root planing FM-SRP Non surgical periodontal treatment will be performed in all dentition within 24 hours | Procedure: Full mouth scaling and root planing Supra- and sub-gingival mechanical instrumentation of the root surface of the whole dentition within 24 hours. |
| Active Comparator: Quadrant scaling and root planing Q-SRP Non surgical periodontal treatment will be performed in all dentition subdivided in four appointments. Each appointment will be performed in one week interval. In each appointment only a "quadrant" of the dentition will be instrumented. | Procedure: Quadrant scaling and root planing Supra- and sub-gingival mechanical instrumentation of the root surface will be performed in all dentition subdivided in four appointments. Each appointment will be performed in one week interval. In each appointment only a "quadrant" of the dentition will be instrumented. |
資格標準
| 有資格學習的年齡 | 18 Years 至 18 Years |
| 有資格學習的性別 | All |
| 接受健康志願者 | 是 |
| 標準 | Inclusion Criteria: - Patients affected by Periodontal Disease - 20% of periodontal pockets of the entire dentition - 20% bleeding on probing of the entire dentition - documented radiographic bone loss - diagnosis of Obesity as measured through Body Mass Index (BMI) superior than 30 Exclusion Criteria: - age younger than 18 years and older than 80 years - pregnant or lactating females - need of antibiotic coverage for periodontal treatment - treatment with statin and/or acetylsalicylic acid - BMI > 35 |
結果
主要結果指標
1. Levels C-Reactive Protein [Baseline, 24 hours and 3 months after treatment]
次要成果指標
1. Full Mouth Plaque Score (FMPS) [Baseline and 3 months after treatment]
2. Full Mouth Bleeding Score (FMBS) [Baseline and 3 months after treatment]
3. Pocket probing depth (PPD) [Baseline and 3 months after treatment]
4. Clinical attachment level (CAL) [Baseline and 3 months after treatment]
5. Recession of the gingival margin (REC) [Baseline and 3 months after treatment]
6. Triglycerides [Baseline, 24 hours and 3 months after treatment]
7. Low-density lipoprotein (LDL) [Baseline, 24 hours and 3 months after treatment]
8. High-density lipoprotein (HDL) [Baseline, 24 hours and 3 months after treatment]
9. Cholesterol [Baseline, 24 hours and 3 months after treatment]
10. Glycaemia [Baseline, 24 hours and 3 months after treatment]
11. Glycated Hemoglobin [Baseline and 3 months after treatment]
12. Insulin [Baseline, 24 hours and 3 months after treatment]
13. Systolic Blood Pressure (SBP) [Baseline, 24 hours and 3 months after treatment]
14. Diastolic Blood Pressure (DBP) [Baseline, 24 hours and 3 months after treatment]
15. Endothelial Function [Baseline, 24 hours and 3 months after treatment]
