Exercise Rehabilitation in Veteran Cancer Survivors
關鍵詞
抽象
描述
Persistent or chronic neuropathic pain, either post-thoracotomy persistent pain (PTPP) or chemotherapy-induced peripheral neuropathy (CIPN) occurs in a majority of lung cancer patients. Thus, not only is this neuropathic pain widespread; there is no way to prevent its development, and long-term use of opioids for control of symptoms could result in addiction. Ultimately, PTPP and CIPN can lead to long-term suffering and disability during the post-treatment phase.(NSCLC), which represents about 85% of lung cancer cases.This is the first project of its kind and the potential impact of this research is large, because exercise training will be a prescription and the first approach for which NSCLC survivors can self-manage chronic neuropathic pain. The ultimate goal of the investigators' work is to reduce neuropathic pain for the growing population of cancer survivors while simultaneously reducing the need for problematic pharmacologic management. Therefore, results of this study have potential for high impact on symptom care because it will allow effective neuropathic pain treatment to be in full control of the Veteran, and likely restore function that is lost during the chronic pain experience.
Specific Aims:
1. To determine the feasibility of conducting an exercise rehabilitation intervention in Veterans with NSCLC and PTPP or CIPN.
2. To determine the effects of a VAMHCS-supervised activity rehabilitation program on chronic pain, and sensory thresholds (thermal, static, and dynamic) compared to delayed control.
3. To assess changes in fitness, strength, physical function, fatigue, and quality of life (QoL) after activity-based rehabilitation compared to control period.
日期
| 最後驗證: | 06/30/2020 |
| 首次提交: | 08/02/2018 |
| 提交的預估入學人數: | 08/02/2018 |
| 首次發布: | 08/07/2018 |
| 上次提交的更新: | 07/14/2020 |
| 最近更新發布: | 07/15/2020 |
| 實際學習開始日期: | 08/18/2019 |
| 預計主要完成日期: | 12/29/2021 |
| 預計完成日期: | 12/29/2022 |
狀況或疾病
干預/治療
Behavioral: Exercise Rehabilitation
Other: Control
相
手臂組
| 臂 | 干預/治療 |
|---|---|
| Other: Control Participants maintain their current activity level. | Other: Control Participants are instructed to maintain current activity level and are monitored for changes. |
| Active Comparator: Exercise Rehabilitation Participants will exercise 2x/week at training facilities and at home one day a week. | Behavioral: Exercise Rehabilitation This training is designed to improve fitness, target the major muscle groups for strength, and to improve balance. Aerobic exercise of walking on a treadmill will be performed. Thera-Bands will be used for resistance exercise for the lower and upper body. Balance program includes core exercises (stepping, weight shifts, etc.) and other progressive exercises. |
資格標準
| 有資格學習的年齡 | 60 Years 至 60 Years |
| 有資格學習的性別 | All |
| 接受健康志願者 | 是 |
| 標準 | Inclusion Criteria: 1. Age 60-80 years 2. Diagnosis with lung cancer 3. History of treatment with either thoracotomy procedure or neurotoxic chemotherapy or both 4. Completion of thoracotomy or chemotherapy > or = 6 months 5. Ability to walk on a treadmill 6. Karnofsky performance status > 70 7. Score > 1 Neuropathic Pain Scale Exclusion Criteria: 1. Presence of metastatic (stage IV) 2. Life expectancy < 6 months 3. Musculoskeletal or medical conditions which preclude participation in an exercise program |
結果
主要結果指標
1. Pain Visual Analog Scale Change [Measured at baseline, after 6 weeks control, and after 6 week intervention]
次要成果指標
1. Patient-Reported Outcomes Measurement System Neuropathic Pain Quality (PROMIS-PQ Neuro) Change [Measured at baseline, after 6 weeks control, and after 6 week intervention]
2. Fitness Change [Measured at baseline, after 6 weeks control, and after 6 week intervention]
3. Strength Change [Measured at baseline, after 6 weeks control, and after 6 week intervention]
4. Pain change [Measured at baseline, after 6 weeks control, and after 6 week intervention]
