American journal of medical genetics. Supplement 1987
Caffeine induces cardiac and other malformations in the rat.
只有註冊用戶可以翻譯文章
登陸註冊
鏈接已保存到剪貼板
關鍵詞
抽象
At various gestational periods, caffeine was injected intra-arterially or intraperitoneally into pregnant rats. The teratogenic effects of caffeine on the fetal heart were dose dependent and detectable at relatively low concentrations. The most susceptible stage was during septation of the heart. The most common cardiovascular malformation was ventricular septal defect. Extracardiovascular anomalies, such as decreased thymic weight and degeneration of the lens, were found in all fetuses; skeletal malformations were found in some fetuses.