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Molecules 2013-Jul

Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.

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Hui-Chi Huang
Ming-Kuem Lin
Syh-Yuan Hwang
Tsong-Long Hwang
Yao-Haur Kuo
Chi-I Chang
Chung-Yi Ou
Yueh-Hsiung Kuo

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抽象

Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.

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