17 alpha hydroxyprogesterone/atrophy

The experimental data on the pharmacological activity of the modified analogs++ of 17 alpha-hydroxyprogesterone are presented. A high gestagenic activity was shown to be related to the presence of the methyl group in position 6, the double bond in position C6-C7, the hydroxyl and acetoxy groups in

In an attempt to evaluate possible adrenal abnormalities in Alzheimer's disease (AD), prestimulus levels and ACTH-stimulated serum levels of steroid hormones, corticosteroid-binding globulin (CBG), and insulin-like growth factor I (IGF-I) were measured in 18 patients with early AD (8 men, 10 women;

Concentrations of testosterone, dihydrotestosterone, androstenedione, progesterone, 17 alpha-hydroxyprogesterone, and estradiol were measured by radioimmunoassay in the amniotic fluid and maternal peripheral blood obtained from normal pregnancies between 14 and 40 weeks of gestation. There was a sex

By 10 days after neonatal thymectomy, the areas of lymphocytic depletion were being repopulated by plasma or reticular cells. Subsequently, ovarian dysgenesis was observed in 50-day-old thymectomized female rats as hyperplasia of ovarian interstitial cells an an enhanced degeneration of follicles.

Eight-week-old female NMRI-mice treated with 5 micrograms diethylstilbestrol (DES) or vehicle (olive oil) from d 1 to 5 after birth were hypophysectomized or sham operated. Thirty days after the operation, homogenates were prepared from the ovaries and incubated at 37 degrees C in the presence of

The regulation of angiogenesis in the ovarian follicle and corpus luteum is unclear. Steroids are produced at very high concentrations in these tissues and we therefore examined the effect of steroids on angiogenesis in vitro. Explants of rat aorta were embedded in collagen gel and cultured in