lysine 2000 mg tablets/day supplementation

Diarrhea

lysine supplementation

Placebo

Mirpur

Lysine Trial in Adults With Diarrhoea

Efficacy of Lysine Supplementation in Reducing Attack Rates of Diarrhea in Adults: a Community-based Randomized Trial in Urban Bangladesh

Primary outcome variable will be a decrease in incidence/attack rate of diarrhea among the subjects over the six-month period of lysine supplementation.

Secondary outcome variables will include diarrheal duration and severity assessed by a clinical score. Changes in immunological parameters including C3, total T-cell population, T-cell subset (CD4, CD8), natural killer cells as well as C-reactive protein and hemoglobin over time will also be assessed as outcome variables

International Centre for Diarrhoeal Disease Research, Bangladesh

A Very Low Carbohydrate Diet was administered for four weeks. VLCD = <20g/day of carbohydrates

Four Week Very Low Carbohydrate Diet

Sex: Female, Male

Region of Enrollment

Adequate relief was measured as the primary endpoint via a single item Adequate Relief Question asking "Over the past week have you had adequate relief of your symptom experience". Higher scores represent greater levels of adequate relief over the week prior to the assessment. Participants completed this 1-item questionnaire at the end of each of weeks of the study, assessing whether they had adequate relief of their IBS symptoms for the week.
A responder was defined as reporting adequate relief in at least 2 of the 4 weeks on the VLCD.

Number of Subjects Reporting "Adequate Relief" From IBS Symptoms for the Previous Week. Adequate Relief Was a "True/False" Item.

Stool Frequency was measured as number of stools per day

Impact of Very Low Carbohydrate Diet on Stool Frequency

Units of measurement on the Sickness Impact Profile were ordinal rated scored. Information on scoring use and interpretation of the Sickness Impact Profile, readers are encouraged to read Bergner et. al. 1981 - Bergner, M., Bobbit, R.A., Carter, W.B. et all (1981) the Sickness Impact Profile: Development and final revision of a health status measure. Medical Care, 19:787-805 The SIP measures sickness-related dysfunction based on behavior in order to provide a measure of health status that will aid in assessing the outcome of health care services.

Sickness Impact Profile

Two weeks of a carbohydrate rich diet was followed by four weeks of A Very Low Carbohydrate Diet. VLCD = <20g/day of carbohydrates

Standard Diet Then Very Low Carbohydrate Diet

Two Week Standard Diet

Stephan R. Weinland, Ph.D.

Diarrhea Predominant Irritable Bowel Syndrome

4 weeks on strictly controlled low carbohydrate diet

5 hydroxytryptamine/diarrhea

Lysine Trial in Adults With Diarrhoea

Effects of a Very Low Carbohydrate Diet on Symptoms of Irritable Bowel Syndrome (IBS)

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