afraegle paniculata/xanthotoxin

Seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 Ames tester strains (TA92, TA94, TA97, TA98, TA100, TA102). The eight compounds are chemicals isolated from three Nigerian medicinal

Xanthotoxin, xanthotoxol and marmesin, three coumarins isolated from Afraegle paniculata, have been treated for anti-inflammatory activity following oral administration. The investigations have shown that xanthotoxol and marmesin are devoid of such activity and that xanthotoxin has some activity.

The isolation of the coumarins xanthyletin, imperatorin, (+)-heraclenin and xanthoxyletin from the rootbark of A. Paniculata (Schum. et Thonn.) Engl. is reported. From the heartwood of the same plant the coumarins scoparon, xanthotoxin, imperatorin, (+)-heraclenin, 6-hydroxy-7-methoxy-coumarin and