althaea leiocarpa/obesity

In order to see whether weanling normophagic rats with hypothalamic obesity (VMNL rats) become hyperphagic and more obese than when fed lab chow, and to see in addition whether there is a possible sex difference in whatever response is found, male and female VMNL rats were fed lab chow for 14 days

Similar to drugs of abuse, the hedonic value of food is mediated, at least in part, by the mesostriatal dopamine (DA) system. Prolonged intake of either high calorie diets or drugs of abuse both lead to a blunting of the DA system. Most studies have focused on DAergic alterations in the striatum,

Male weanling rats received dorsomedial hypothalamic nucleus lesions (DMNL) or sham operations and were fed for 173 postoperative days a high-fat diet and given a 32% sucrose solution as drinking fluid. This was supplemented with chocolate chip cookies, potato chips and marshmallows. Other DMNL and