anisodamine/ischemia

OBJECTIVE To study the effect of anisodamine on neuronal death and hydroxyl radical (OH.) production during forebrain ischemia-reperfusion in gerbils. METHODS The tested gerbils were divided into 3 groups, including sham-operated, control and anisodamine groups. In each group, there were 8 animals

OBJECTIVE To determine if anisodamine is able to augment mucosal perfusion during gut I/R ischemia-reperfusion. METHODS A jejunal sac was formed in Sprague Dawley rat. A Laser Doppler probe and a tonometer were inserted into the sac which was filled with saline. The superior mesenteric artery was

In order to investigate the mechanisms of acute cerebral ischemia, and to look for effective drugs on cerebral resuscitation, we made a model of acute complete global brain ischemia, reperfusion and resuscitation on rats according to Garavilla's method. Our results showed that the event of cerebral

OBJECTIVE To observe the effect of anisodamine (Ani) injection on the survival rate and histologic result of flaps with ischemia-reperfusion injury, so as to demonstrate the protective effect of Ani on the flap survival. METHODS A total of 48 healthy male Wistar rats were randomly divided into model

The effects of bepridil (Bep) in combination with anisodamine (Ani) on myocardial ischemia and reperfusion injury induced by ligating the left coronary artery were studied in rats. Administration of a combination of Bep and Ani was found to decrease the incidence of arrhythmia induced by myocardial

The aim of the present study was to investigate the cardioprotective effects of anisodamine against myocardial ischemia/reperfusion (I/R) injury and the molecular mechanisms involved. The present results demonstrated that anisodamine attenuated myocardial infarct sizes, decreased the levels of

Anisodamine is an ancient Chinese medicine derived from Tibet as a belladonna alkaloid, which is usually used for improvement of blood circulation in patients with organ phosphorus poisoning or shock. In this study, for the first time, we report its cardioprotective effects on preventing

OBJECTIVE Anisodamine (Ani), an alkaloid first isolated in China. To study the relationship between the protective effects of Ani on myocardial cells of reperfused injuries and the antilipid peroxidation. METHODS Coronary ligation for 15-min followed by 10 min reperfusion was performed in

Anisodamine is an alkaloid isolated from a Chinese plant, which was subsequently synthesized. Its chemical structure is similar to atropine. It inhibits cholinergic nerve function, improves microcirculation, and was reported to have a protective effect on reperfusion injury in various organs. We

Anisodamine is a multi-functional bio-alkaloid with vascular activity. Our previous studies have revealed that anisodamine protects the heart from ischemia/reperfusion (I/R) injury induced by cardiac arrest (CA) and resuscitation. This study aimed to explore whether the protective effect of

Myocardial ischemia/reperfusion (MIR) injury easily occurrs during cardiopulmonary bypass surgery in elderly patients. In an attempt to develop an effective strategy, we employed a pig model of MIR injury to investigate the maximum rate of change of left ventricular pressure, left ventricular

After 30-min ischemia and 60-min reperfusions in rats by ligating bilateral vertebral and common carotid arteries, the brain calcium contents were increased from 171 +/- 6 micrograms in control group to 192 +/- 10 micrograms with abnormal EEG activities and ischemic injury in the brain tissues.

Anisodamine was used as an antishock (chiefly septic) drug beginning in the early 1960s in China. Its underlining mechanism was believed to be due to its vasodilative action. But in normal animals it only produces slight vasodilation. Our work during the recent 15 years proved that anisodamine is

Intracoronary infusion of some drugs may induce superimposed coronary vasodilation upon endogenous vasodilation during myocardial ischemia, which was suggested as coronary vasodilator reserve. For an investigation of this phenomenon, 8 pigs were anesthetized, chest-opened, LAD (left anterior

OBJECTIVE To investigate the protection of anisodamine on cardiac ischemia/reperfusion (I/R) injury by oxidative stress by observing the changes in oxidation and antioxidant markers in plasma and myocardium, and the damage of cardiac mitochondria structure in pigs with cardiac arrest