3 結果
The basic pathophysiology of intervertebral disc degeneration and low back pain remains unclear. It has been hypo-thesized a role of biochemical mediators of inflammation and tissue degradation in intervertebral disc degeneration and herniation. Chitinase 3-like protein 1 (YKL-40) is a glycoprotein
OBJECTIVE
Increased neurotrophin activity in degenerative intervertebral discs (IVDs) is one potential cause of chronic low-back pain (LBP). The aim of the study was to assess if nerve growth factor (NGF) might alter gene expression of IVD cells and contribute to disc degeneration by enhancing
Intervertebral disc degeneration (IDD) is the main cause of low back pain and the mechanism of which is far from fully revealed. Although inflammation directed nucleus pulposus (NP) extracellular matrix metabolism dysregulation is known to be the main cause of the degeneration process, few is known