creatine/fever

Following a synthetic description of malignant postoperative hyperthermia, the author recommends the inclusion of serum creatine phosphokinase (CPK) assay in the list of preoperative laboratory tests for all patients scheduled for major surgery. Because this serum enzyme is most often altered in

We investigated 56 families afflicted with malignant hyperpyrexia. One hundred and twenty-four individuals within these families had had an episode of malignant hyperthermia, of whom we saw seventy-two. Serum creatine phosphokinase (CPK) was statistically higher in affected individuals and in close

Erythrocyte osmotic fragility, serum creatine kinase (CK) and its isoenzymes (CK-MM, CK-MB and CK-BB) were determined in pigs susceptible (SMH) and resistant (RMH) to malignant hyperthermia at three different body weights (Group 1, 10 to 25 kg; Group 2, 26 to 55 kg; Group 3, 56 to 95 kg). The

OBJECTIVE To study the effect of ribavirin treatment on kinetics of serum creatine phosphate kinase isoenzyme(CK-MB) of patients with hemoarrhagic fever with renal syndrome(HFRS). METHODS CK-MB levels in 155 HFRS patients treated with larger dose of ribavirin and with routine therapeutic dose were

The muscle biopsy from a 12-year-old boy with chronic creatine kinase elevation was studied by electron microscopy. At the age of 7 years the patient had a possible abortive attack of malignant hyperthermia. The biopsy specimen contained many fibres with segmental contracture and necrosis; thin

The clinical and laboratory findings in 4 children with signs of malignant hyperthermia are reported. In all cases an extraordinary elevation of creatine kinase activity in serum was observed. By investigation of the creatine kinase isoenzyme activities we tried to determine the origin of creatine

Two hundred and seven boars entering a Record of Performance Test Station at New Hamburg, Ontario were screened for susceptibility to malignant hyperthermia or the porcine stress syndrome. Screening tests included the determination of whole blood creatine kinase levels by a commercially available

We report on three families with the Gly341Arg ryanodine receptor gene (RYR1) mutation. Thirteen individuals were heterozygote carriers of the Gly341Arg mutation and had clearly positive in vitro contracture tests, indicating malignant hyperthermia susceptibility. Nine Gly341Arg mutation positive

One hundred thirty-one patients who were referred for muscle biopsy for in vitro contracture testing (IVCT) for susceptibility to malignant hyperthermia (MH) were studied. Serum creatine kinase (CK) levels were determined routinely before biopsy by the hospital clinical laboratories. Thirty-four had

We describe 49 neurologically asymptomatic patients with persistently increased serum creatine kinase (CK) levels (idiopathic hyperCKemia or IHCK) who were referred to our institution for diagnostic muscle biopsy, including malignant hyperthermia (MH) susceptibility testing between 1979 and 1993.

Skeletal muscle may release creatine kinase (CK) during a malignant hyperthermia (MH) episode; however, muscle damaged during surgery may also release CK. This study examined the overlap between peak plasma CK levels in patients suspected of having had a MH episode (data obtained from North American

Serum creatine phosphokinase (CPK) activity was measured in 10 German Landrace pigs from 11 to 28 weeks of age. A pronounced age dependence of serum enzyme activity was observed, peak activity occurring at 19 weeks of age. At the end of the growth period, when the pigs were challenged with halothane

The serum activity of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatine kinase (CK), and gamma-glutamyltransferase (GGT) was determined at the time of first and subsequent treatments in milk fever cows which responded differently to treatment, and in a number of healthy,

The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS, an animal model has been developed. Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms

Effects of heating (36 degrees, relative air humidity 80-90%, 4 hours) and joint beta (85Kr)-X-ray-irradiation of rats, given separately and simultaneously, in doses 2.5 krad+ + 25 r, 2.5 krad + 50 r, 3.05 krad + 100 r, 4.45 krad + 250 r, 7.4 krad + 400 r on creatine kinase activity in brain and