diabetic angiopathies/carbohydrate

Experience in the treatment of 77 patients with diabetic angiopathy of the lower limbs is discussed. Various pyonecrotic complications developed in 44% of cases. Laboratory and instrumental diagnostic methods included general clinical, biochemical, and coagulation tests, angiography, dopplerography,

Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that

Today diabetes mellitus is one of the most important problems of modern medicine. This review provides an analysis of the reported data on the problem of vascular lesion in patients with diabetes mellitus. The authors consider the problems of diabetes mellitus epidemiology and the incidence of

The effects of streptozotocin-induced carbohydrate intolerance on the basement membrane of muscle capillaries were studied in 5 adult rhesus monkeys. Biopsies were obtained 6 to 15 months after administration of the drug. Although wide variations in the thickness of basement membranes were observed

1. Abnormalities in glycoprotein metabolism are believed to play a role in diabetic microangiopathy. We have therefore measured the urinary excretion of carbohydrate-containing materials in normal and diabetic subjects. 2. Diabetic subjects were found to excrete excessive quantities of such

The level of glycosylated hemoglobin (Hb AIc), the concentration of glycosylated proteins in red blood cell membranes (GPCM), and fructosamine were measured in patients with different carbohydrate metabolism abnormalities (glucose tolerance test disorders, insulin-dependent diabetes mellitus/IDDM/).

It has been shown that the metabolic responses to the ingestion of carbohydrates depend upon a) the type of the ingested carbohydrate and b) the genetic build-up of the recipient. In the non-susceptible animal, the ingestion of high sucrose, fructose or glucose diets will ensue in "normal" metabolic

Vascular disease underlies many of the complications of diabetes and includes coronary, cerebral, renal, peripheral and retinal vascular abnormalities. Magnesium (Mg) and potassium (K) deficiencies occur frequently in diabetic patients. Because of the vasoconstrictive effects of hypomagnesemia and

An elevated level of the products of lipid peroxidation was revealed in the erythrocytes of patients with diabetic microangiopathies as compared to healthy donors. The level of the products of lipid peroxidation did not depend on the severity of disease, the degree of compensation of carbohydrate

The therapeutic effect of pentoxyphilin substance--Trental, was followed up in 102 diabetics (35 females and 67 males) aged from 34 to 79 via a broad complex of clinical and paraclinical methods. Favourable results were found in 90.4 per cent of the treated; excellent effect--in 42.3 per cent of the

Haemolytic anaemia associated with prominent red cell fragmentation is described in seven patients with long-standing diabetes mellitus. A common freature in the patients was severe microangiopathy as detected by retinal examination and microscopic examination of the kidneys. Renal or pancreatic

Diabetes mellitus is a chronic disease characterized by hyperglycaemia and carbohydrate, fat and protein metabolism abnormalities, all due to an impairment in insulin homeostasis and a diffuse microangiopathy most involving retina, kidney and nerves. Several mechanisms are altered at a molecular

Patients with diabetes mellitus accounted for 7% of all hospitalized patients. The authors analyse the treatment of 126 patients in whom diabetes mellitus was complicated by angiopathies of the lower limbs. Patients over 60 years of age accounted for 60.3% of cases. Concomitant diseases were found

Pathophysiology of diabetic microangiopathy is unclear, but hyperglycemia is admitted as an important factor. In three patients having microangiopathy with lesions very similar to those of diabetes (one nodular glomerulosclerosis, two retinopathies), glucose tolerance was found normal. Such cases,