endolymphatic hydrops/albumin

OBJECTIVE To investigate allergic endolymphatic hydrops (EH) and the effect of leukotriene receptor antagonist (LTRA). METHODS Experiment 1: Thirty-six guinea pigs were actively sensitized with DNP-ascaris twice and were provoked with DNP-bovine serum albumin 1 week after the second sensitization.

The endolymphatic sac (ES) is an inner ear organ that is connected to the cochleo-vestibular system through the endolymphatic duct. The luminal fluid of the ES contains a much higher concentration of proteins than any other compartment of the inner ear. This high protein concentration likely

A study of the permeability of the middle ear-inner ear interface for macromolecules was carried out in chinchillas with open and obstructed eustachian tubes utilizing tritiated human serum albumin and immunoelectrophoresis. Tritiated albumin was placed in the round window niche area or normal

Guinea pigs were passively sensitized by sera containing antidinitrophenyl reaginic antibody and specifically challenged by dinitrophenyl-bovine serum albumin injected through the stylomastoid foramen. Nystagmus, head deviation, negative summating potentials on electrocochleography, and an increase

Ménière's disease (MD) is a disorder of the inner ear characterized by an insidious onset and aspecific symptoms, such as dizziness, vertigo, tinnitus, and hearing loss, that may become very debilitating. The presence of endolymphatic hydrops is a common feature in MD patients, but the

A round window membrane permeability study of macromolecules in otitis media, using tritiated normal human serum albumin, was done in cats. Eustachian tube obstruction was used to induce otitis media in ten animals. Samples of perilymph in obstructed and normal control ears were studied after 25

The inner ear must maintain a delicate homeostasis to preserve high sensitivity to acoustic and vestibular inputs. Various experimental conditions were imposed upon chinchillas to help identify these homeostatic mechanisms for the inner ear fluids. Radioactive ions (sodium, chloride, and calcium)