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A case of acute poisoning with ethylene glycol butyl ether (EGBE) is reported in a chronic alcohol abuser. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. Following supportive treatment and
A 33-year-old female dialysis patient suffered from osteomyelitis and luxation of the dens axis with cervical myelopathy. In the past she had had three attacks of anaphylaxis after treatment with dialyzers that had been sterilized with ethylene oxide. IgE-type antibodies directed against human serum
Controlled-release polymers have facilitated the interstitial delivery of drugs within the central nervous system. In the present study, dexamethasone was incorporated into ethylene-vinyl acetate polymers, which were then implanted adjacent to a 9L gliosarcoma in the brain of Fischer 344 rats. The
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To report the effects of inhaling vapor from water-soluble paint after a recent encounter with 16 patients treated in our emergency department.
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We examined a series of chest computed tomography (CT) images from the 16 affected patients. Computed tomography was carried out on
Secretory phospholipases A2 (PLA2) from Naja naja naja (cobra snake) venom, from Bothrops neuwiedii (crotalid snake) venom (two isoforms) and from bee venom were modified with tresylated monomethoxy poly(ethylene glycol) (TMPEG). The kinetic and inflammatory properties of the adducts (PEG-PLA2) were
An acute inhalation toxicity study in several species of animals with an ethylene oxide/propylene oxide copolymer (EO/PO) having a molecular weight of 4000 [UCON-50-HB-5100, CAS #9038-95-3] was designed to determine if any species variation could be shown. Species tested included: rats, mice,
Previous studies have shown that aerosols of an ethylene oxide/propylene oxide copolymer (UCON 50-HB-5100) produced an inflammatory response in lungs of rats in short-term repeated exposures at relatively low concentrations. This study was carried out on related polyalkylene glycols (EO/PO
Ethylene glycol monohexyl ether (EGHE) and diethylene glycol monohexyl ether (DGHE) are glycol ethers used as industrial solvents and coating materials, and whose acute handling hazards were investigated. Acute peroral LD50 values in the rat were for EGHE 1.67 ml/kg (males) and 0.83 ml/kg (females),
The ethylene oxide/propylene oxide (EO/PO) polymers evaluated in this study have previously been shown to have a low order of toxicity and/or irritancy by ocular, dermal, or oral routes of administration. These studies evaluated the acute inhalation toxicity of respirable aerosols of three EO/PO
Ethylene glycol (EG), commonly found in antifreeze and deicing solutions, continues to be a cause of morbidity and mortality in the pediatric population. EG metabolism produces toxins that cause metabolic acidosis and calcium oxalate deposition throughout the body. Deposition in the central nervous
Ethylene glycol dimethyl ether (EGdiME) was administered by gavage to pregnant Sprague-Dawley rats in doses of 30, 60, 120, 250, 500, and 1000 mg/kg/day from day 8 through day 18 of gestation. The effects of the compound on maternal weight gain, length of gestation, perinatal mortality,
Sixteen patients are presented who suffered from substantial tissue burn subsequent to the insertion of textured silicone gel breast implants for cosmetic purposes. The injuries may have been caused by ethylene oxide (ETO) residues in the implants used for the surgical procedure. The manufacturer
Exposure of female mice to ethylene oxide by inhalation 1 or 6 h after mating produced not only multitemporal death of conceptuses but also high rates of abnormalities among surviving fetuses. In contrast, only marginal effects were observed when females were exposed 9 or 25 h after mating. The