Preterm Premature Rupture of Membrane

Loading dose: Oral Nifedipine 20 mg LP at T0 and T0.5 (i.e. 30 min), total=2x20 mg Maintenance dose: Oral Nifedipine 20 mg LP at T3, then 1 pill every 8 hr for 48 hr (i.e. T11, T19, T27, T35 and T43, total=6x20 mg)

Nifedipine

Oral Placebo of Nifedipine 20 mg, at T0, T0.5, T3, T11, T19, T27, T35 and T43

Placebo of Nifedipine

Trousseau University Hospital

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation: a Double-blinded Randomized Controlled Trial

Composite outcome including fetal death, neonatal death and/or neonatal severe morbidity (mechanical ventilation ≥ 48 hrs, severe bronchopulmonary dysplasia, severe intraventricular hemorrhage, cystic periventricular leucomalacia, neonatal early-onset sepsis, necrotizing enterocolitis, retinopathy of prematurity).

Latency duration (defined as the duration from PPROM to delivery)

Pregnancy prolongation beyond 48 hours after randomization

Pregnancy prolongation beyond 1 week after randomization

Endometritis, based on clinical diagnosis associating fever (temperature ≥ 38.0°C) with uterine tenderness, purulent or foul-smelling lochia, and in the absence of any other cause.

Mild or moderate bronchopulmonary dysplasia

Death between discharge and follow up at 2 years

Assistance Publique - Hôpitaux de Paris

INSERM U1153

Ministry of Health, France

Groupe de Recherche en Obstétrique et Gynécologie

Neonatal SEPSIS

Nosocomially Acquired Neonatal Sepsis

Assuit University NICU of Children Hospital

A Study On the Risk of Nosocomial Infection in Mechanically Ventilated Neonate In NICU of Assiut University Children Hospital (Nicu Eta)

A Study On the Risk of Nosocomial Infection in Mechanically Ventilated Neonate In NICU of Assiut University Children Hospital PROTOCOL OF THESIS Descriptive Study

to determine incidence and prevalence of neonatal sepsis on mechanically ventilated neonate

serial endo tracheal aspirate ever three day to predict neonatal sepsis and type of organisms causing sepsis in ventilated neonate,antibiotic proper usage

Abd Elrhman Fawzy

M.B.B.CH resident doctor. principal investigator

Assiut University

Amniotic fluid analysis by blood gas device: evaluate the possible association between maternal inflammation and amniotic fluid pH two groups will be designed. One group will consist of infants born to mothers with infection/inflammation whereas the control group will consist of infants born to mothers without infection/inflammation. In all deliveries amniotic fluid will be taken and will be analyzed by blood gas device.

Amniotic fluid analysis by blood gas device: The control group will consist of infants born to mothers without infection/inflammation. In all deliveries amniotic fluid will be taken and will be analyzed by blood gas device.

Respiratory Distress Syndrome

Transient Tachypnea of Newborn

Intrauterine Growth Retardation

Amniotic fluid analysis by blood gas device in maternal inflammation group vs normal pregnancy group

Amniotic fluid analysis by blood gas device

Kanuni Sultan Suleyman Training and Research Hospital

The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies

Amniotic fluid will be analysed for the value of its pH

Amniotic fluid will be analysed for the value of its contents of electrolytes such as sodium, potassium, chlorid.

Amniotic fluid will be analyzed for primary outcome measures by conventional methods and devices.

fetal distress/inflammation

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation

A Study On the Risk of Nosocomial Infection in Mechanically Ventilated Neonate In NICU of Assiut University Children Hospital (Nicu Eta)

The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies

Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen

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