fraxinellone/melia azedarach

In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, twenty-three new fraxinellone-based hydrazone derivatives were smoothly prepared from fraxinellone via regioselectively allylic oxidation in the presence of selenium dioxide or

In continuation of a program aimed at the discovery and development of natural products-based insecticidal agents, two series of novel fraxinellone-based esters were synthesized by modification at the C-4 or C-10 position of fraxinellone and evaluated for their insecticidal activity against the

Two new degraded limonoids, azedararide and 12alpha-acetoxy fraxinellone, were isolated together with two known degraded limonoids, fraxinellone and fraxinellonone, as ichthyotoxic substances from the root bark of Melia azedarach. Their structures were elucidated by spectroscopic and chemical means.

The roots of Melia azedarach yielded three new degraded limonoids: teracrylmelazolide A, melazolide A and teracrylmelazolide B, possessing a previously undescribed skeleton. The known pyroangolensolide, fraxinellone and its three derivatives, 30-hydroxyfraxinellone, 9 alpha- and 9