geographic atrophy/hypoxia

Age-related macular degeneration is a common cause of blindness. Its incidence is increasing, partly due to the advancing age of the population in North America and Europe, but there is no doubt that the age-adjusted rates are also increasing, which points to some environmental influence. The

Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration. In this study, we generated CCL2(-/-)CX3CR1(GFP/GFP) mice on the C57BL/6J background. Retinal degeneration was not detected in